Hsieh HP - Search Results

1

A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects.

Hsu YT, Chen SR, Chang YC, Chang HF, Yeh TK, Chuang JY, Loh HH, Hsieh HP, Ueng SH, Yeh SH. Hsu YT, et al. Among authors: hsieh hp. Eur J Med Chem. 2023 Oct 5;258:115608. doi: 10.1016/j.ejmech.2023.115608. Epub 2023 Jul 1. Eur J Med Chem. 2023. PMID: 37437352

2

Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents.

Liou JP, Mahindroo N, Chang CW, Guo FM, Lee SW, Tan UK, Yeh TK, Kuo CC, Chang YW, Lu PH, Tung YS, Lin KT, Chang JY, Hsieh HP. Liou JP, et al. Among authors: hsieh hp. ChemMedChem. 2006 Oct;1(10):1106-18. doi: 10.1002/cmdc.200600125. ChemMedChem. 2006. PMID: 16952120

3

Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: application to a pharmacokinetic study.

Chang YW, Chen WC, Lin KT, Chang L, Yao HT, Hsieh HP, Lan SJ, Chen CT, Chao YS, Yeh TK. Chang YW, et al. Among authors: hsieh hp. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 1;846(1-2):162-8. doi: 10.1016/j.jchromb.2006.08.040. Epub 2006 Sep 26. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17005456

4

Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.

Yao HT, Wu YS, Chang YW, Hsieh HP, Chen WC, Lan SJ, Chen CT, Chao YS, Chang L, Sun HY, Yeh TK. Yao HT, et al. Among authors: hsieh hp. Drug Metab Dispos. 2007 Jul;35(7):1042-9. doi: 10.1124/dmd.106.014597. Epub 2007 Apr 2. Drug Metab Dispos. 2007. PMID: 17403915

5

Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents.

Lai MJ, Kuo CC, Yeh TK, Hsieh HP, Chen LT, Pan WY, Hsu KY, Chang JY, Liou JP. Lai MJ, et al. Among authors: hsieh hp. ChemMedChem. 2009 Apr;4(4):588-93. doi: 10.1002/cmdc.200800405. ChemMedChem. 2009. PMID: 19266513

6

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

Wu YS, Coumar MS, Chang JY, Sun HY, Kuo FM, Kuo CC, Chen YJ, Chang CY, Hsiao CL, Liou JP, Chen CP, Yao HT, Chiang YK, Tan UK, Chen CT, Chu CY, Wu SY, Yeh TK, Lin CY, Hsieh HP. Wu YS, et al. Among authors: hsieh hp. J Med Chem. 2009 Aug 13;52(15):4941-5. doi: 10.1021/jm900060s. J Med Chem. 2009. PMID: 19586033

7

Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.

Chen CP, Hu CB, Yeh KC, Song JS, Yeh TK, Tung FF, Hwang LL, Tseng HY, Huang YC, Shy HS, Hsieh SH, Shen CC, Wang HS, Hsieh HP, Liou JP, Chao YS, Chen CT. Chen CP, et al. Among authors: hsieh hp, hsieh sh. Anticancer Res. 2010 Jul;30(7):2813-22. Anticancer Res. 2010. PMID: 20683017

8

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

Wu CH, Coumar MS, Chu CY, Lin WH, Chen YR, Chen CT, Shiao HY, Rafi S, Wang SY, Hsu H, Chen CH, Chang CY, Chang TY, Lien TW, Fang MY, Yeh KC, Chen CP, Yeh TK, Hsieh SH, Hsu JT, Liao CC, Chao YS, Hsieh HP. Wu CH, et al. Among authors: hsieh hp, hsieh sh. J Med Chem. 2010 Oct 28;53(20):7316-26. doi: 10.1021/jm100607r. J Med Chem. 2010. PMID: 20961149

9

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

Tung YS, Coumar MS, Wu YS, Shiao HY, Chang JY, Liou JP, Shukla P, Chang CW, Chang CY, Kuo CC, Yeh TK, Lin CY, Wu JS, Wu SY, Liao CC, Hsieh HP. Tung YS, et al. Among authors: hsieh hp. J Med Chem. 2011 Apr 28;54(8):3076-80. doi: 10.1021/jm101027s. Epub 2011 Mar 24. J Med Chem. 2011. PMID: 21434659

10

BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells.

Cheung CH, Lin WH, Hsu JT, Hour TC, Yeh TK, Ko S, Lien TW, Coumar MS, Liu JF, Lai WY, Shiao HY, Lee TR, Hsieh HP, Chang JY. Cheung CH, et al. Among authors: hsieh hp. PLoS One. 2011;6(8):e23485. doi: 10.1371/journal.pone.0023485. Epub 2011 Aug 24. PLoS One. 2011. PMID: 21887256 Free PMC article.

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