Shaldam MA - Search Results

1

2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling.

Shaldam MA, Hendrychová D, El-Haggar R, Vojáčková V, Majrashi TA, Elkaeed EB, Masurier N, Kryštof V, Tawfik HO, Eldehna WM. Shaldam MA, et al. Eur J Med Chem. 2023 Oct 5;258:115610. doi: 10.1016/j.ejmech.2023.115610. Epub 2023 Jun 27. Eur J Med Chem. 2023. PMID: 37437350

2

New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study.

Al-Rashood ST, Elshahawy SS, El-Qaias AM, El-Behedy DS, Hassanin AA, El-Sayed SM, El-Messery SM, Shaldam MA, Hassan GS. Al-Rashood ST, et al. Among authors: shaldam ma. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127611. doi: 10.1016/j.bmcl.2020.127611. Epub 2020 Oct 14. Bioorg Med Chem Lett. 2020. PMID: 33068712

3

Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors.

Shaldam M, Eldehna WM, Nocentini A, Elsayed ZM, Ibrahim TM, Salem R, El-Domany RA, Capasso C, Abdel-Aziz HA, Supuran CT. Shaldam M, et al. Eur J Med Chem. 2021 Apr 15;216:113283. doi: 10.1016/j.ejmech.2021.113283. Epub 2021 Feb 18. Eur J Med Chem. 2021. PMID: 33667848

4

Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors.

Shaldam M, Nocentini A, Elsayed ZM, Ibrahim TM, Salem R, El-Domany RA, Capasso C, Supuran CT, Eldehna WM. Shaldam M, et al. Int J Mol Sci. 2021 Oct 15;22(20):11119. doi: 10.3390/ijms222011119. Int J Mol Sci. 2021. PMID: 34681794 Free PMC article.

5

Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity.

Tawfik HO, Shaldam MA, Nocentini A, Salem R, Almahli H, Al-Rashood ST, Supuran CT, Eldehna WM. Tawfik HO, et al. Among authors: shaldam ma. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1043-1052. doi: 10.1080/14756366.2022.2056734. J Enzyme Inhib Med Chem. 2022. PMID: 35437108 Free PMC article.

6

Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition.

Aboukhatwa SM, Ibrahim AO, Aoyama H, Al-Behery AS, Shaldam MA, El-Ashmawy G, Tawfik HO. Aboukhatwa SM, et al. Among authors: shaldam ma. Bioorg Chem. 2022 Dec;129:106126. doi: 10.1016/j.bioorg.2022.106126. Epub 2022 Sep 7. Bioorg Chem. 2022. PMID: 36108589

7

Synthesis, crystallographic, DNA binding, and molecular docking/dynamic studies of a privileged chalcone-sulfonamide hybrid scaffold as a promising anticancer agent.

Shaldam M, Tawfik H, Elmansi H, Belal F, Yamaguchi K, Sugiura M, Magdy G. Shaldam M, et al. J Biomol Struct Dyn. 2023 Oct-Nov;41(18):8876-8890. doi: 10.1080/07391102.2022.2138551. Epub 2022 Oct 30. J Biomol Struct Dyn. 2023. PMID: 36310097

8

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations.

Al-Karmalawy AA, Nafie MS, Shaldam MA, Elmaaty AA, Antar SA, El-Hamaky AA, Saleh MA, Elkamhawy A, Tawfik HO. Al-Karmalawy AA, et al. Among authors: shaldam ma. J Med Chem. 2023 Jan 12;66(1):777-792. doi: 10.1021/acs.jmedchem.2c01668. Epub 2022 Dec 16. J Med Chem. 2023. PMID: 36525642

9

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors.

Shaldam MA, Almahli H, Angeli A, Badi RM, Khaleel EF, Zain-Alabdeen AI, Elsayed ZM, Elkaeed EB, Salem R, Supuran CT, Eldehna WM, Tawfik HO. Shaldam MA, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2203389. doi: 10.1080/14756366.2023.2203389. J Enzyme Inhib Med Chem. 2023. PMID: 37122176 Free PMC article.

10

Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments.

Al-Karmalawy AA, Rashed M, Sharaky M, Abulkhair HS, Hammouda MM, Tawfik HO, Shaldam MA. Al-Karmalawy AA, et al. Among authors: shaldam ma. Eur J Med Chem. 2023 Nov 5;259:115661. doi: 10.1016/j.ejmech.2023.115661. Epub 2023 Jul 18. Eur J Med Chem. 2023. PMID: 37482023

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