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Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt MF, Maul L, Pani B, Bahriz SM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch M, Kobilka BK. Casiraghi M, et al. Among authors: lefkowitz rj. bioRxiv [Preprint]. 2024 Apr 12:2024.03.28.587240. doi: 10.1101/2024.03.28.587240. bioRxiv. 2024. PMID: 38586060 Free PMC article. Preprint.
How carvedilol does not activate β2-adrenoceptors.
Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. Lefkowitz RJ, et al. Nat Commun. 2023 Nov 30;14(1):7866. doi: 10.1038/s41467-023-42848-5. Nat Commun. 2023. PMID: 38036531 Free PMC article. No abstract available.
Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin.
Kahsai AW, Shah KS, Shim PJ, Lee MA, Shreiber BN, Schwalb AM, Zhang X, Kwon HY, Huang LY, Soderblom EJ, Ahn S, Lefkowitz RJ. Kahsai AW, et al. Among authors: lefkowitz rj. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2303794120. doi: 10.1073/pnas.2303794120. Epub 2023 Oct 16. Proc Natl Acad Sci U S A. 2023. PMID: 37844230 Free PMC article.
Marc G. Caron (1946-2022).
Lefkowitz RJ, Amara SG. Lefkowitz RJ, et al. Nat Neurosci. 2022 Sep;25(9):1120. doi: 10.1038/s41593-022-01145-y. Nat Neurosci. 2022. PMID: 35915165 No abstract available.
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.
Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, Lefkowitz RJ, Blanchard SC, Javitch JA. Asher WB, et al. Among authors: lefkowitz rj. Cell. 2022 May 12;185(10):1661-1675.e16. doi: 10.1016/j.cell.2022.03.042. Epub 2022 Apr 27. Cell. 2022. PMID: 35483373 Free PMC article.
810 results