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Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases.
Yadav R, Sukumaran S, Lutman J, Mitra MS, Halpern W, Sun T, Setiadi AF, Neighbors M, Sheng XR, Yip V, Shen BQ, Liu C, Han L, Ovacik AM, Wu Y, Glickstein S, Kunder R, Arron JR, Pan L, Kamath AV, Stefanich EG. Yadav R, et al. Among authors: pan l. J Pharm Sci. 2023 Nov;112(11):2910-2920. doi: 10.1016/j.xphs.2023.07.005. Epub 2023 Jul 8. J Pharm Sci. 2023. PMID: 37429356 Free article.
Translational and pharmacokinetic-pharmacodynamic application for the clinical development of GDC-0334, a novel TRPA1 inhibitor.
Chan P, Ding HT, Liederer BM, Mao J, Belloni P, Chen L, Gao SS, Joseph V, Yang X, Lin JS, Mitra MS, Putnam WS, Quartino A, Bauer RN, Pan L. Chan P, et al. Among authors: pan l. Clin Transl Sci. 2021 Sep;14(5):1945-1954. doi: 10.1111/cts.13049. Epub 2021 May 31. Clin Transl Sci. 2021. PMID: 34058071 Free PMC article. Clinical Trial.
A Phase 1a Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7303509, an Anti-TGFβ3 Antibody, in Healthy Volunteers.
Han LW, Jamalian S, Hsu JC, Sheng XR, Yang X, Yang X, Monemi S, Hassan S, Yadav R, Tuckwell K, Kunder R, Pan L, Glickstein S. Han LW, et al. Among authors: pan l. Rheumatol Ther. 2024 Jun;11(3):755-771. doi: 10.1007/s40744-024-00670-5. Epub 2024 Apr 25. Rheumatol Ther. 2024. PMID: 38662148 Free PMC article.
Effect of pirfenidone on gastric emptying in a rat model.
Pan L, Gelzleichter T, Chen Y, Burg C, Limb SL, Nguyen L. Pan L, et al. Pulm Pharmacol Ther. 2018 Aug;51:41-47. doi: 10.1016/j.pupt.2018.06.001. Epub 2018 Jun 23. Pulm Pharmacol Ther. 2018. PMID: 29944949 Free article.
7,970 results