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208 results

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Page 1
The Plasmodium Lactate/H+ Transporter PfFNT Is Essential and Druggable In Vivo.
Davies H, Bergmann B, Walloch P, Nerlich C, Hansen C, Wittlin S, Spielmann T, Treeck M, Beitz E. Davies H, et al. Among authors: wittlin s. Antimicrob Agents Chemother. 2023 Aug 17;67(8):e0035623. doi: 10.1128/aac.00356-23. Epub 2023 Jul 10. Antimicrob Agents Chemother. 2023. PMID: 37428074 Free PMC article.
In vivo antimalarial efficacy of Artemisia afra powder suspensions.
Walz A, Lehmann U, Duthaler U, Mäser P, Wittlin S. Walz A, et al. Among authors: wittlin s. Phytomedicine. 2024 May 17;129:155644. doi: 10.1016/j.phymed.2024.155644. Online ahead of print. Phytomedicine. 2024. PMID: 38761524 Free article.
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
Creek D, Giannangelo C, Challis M, Siddiqui G, Edgar R, Malcolm T, Webb C, Drinkwater N, Vinh N, MacRaild C, Counihan N, Duffy S, Wittlin S, Devine S, Avery V, de Koning-Ward T, Scammells P, McGowan S. Creek D, et al. Among authors: wittlin s. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-3251230. doi: 10.21203/rs.3.rs-3251230/v3. Res Sq. 2024. PMID: 38746424 Free PMC article. Preprint.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. Among authors: wittlin s. mBio. 2024 May 8:e0096624. doi: 10.1128/mbio.00966-24. Online ahead of print. mBio. 2024. PMID: 38717141 Free article.
hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
Mambwe D, Coertzen D, Leshabane M, Mulubwa M, Njoroge M, Gibhard L, Girling G, Wicht KJ, Lee MCS, Wittlin S, Moreira DRM, Birkholtz LM, Chibale K. Mambwe D, et al. Among authors: wittlin s. ACS Med Chem Lett. 2024 Mar 18;15(4):463-469. doi: 10.1021/acsmedchemlett.3c00496. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628794 Free PMC article.
Next Generation Chemiluminescent Probes for Antimalarial Drug Discovery.
Hellingman A, Sifoniou K, Buser T, Thommen BT, Walz A, Passecker A, Collins J, Hupfeld M, Wittlin S, Witmer K, Brancucci NMB. Hellingman A, et al. Among authors: wittlin s. ACS Infect Dis. 2024 Apr 12;10(4):1286-1297. doi: 10.1021/acsinfecdis.3c00707. Epub 2024 Apr 1. ACS Infect Dis. 2024. PMID: 38556981 Free PMC article.
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Nguyen W, Boulet C, Dans MG, Loi K, Jarman KE, Watson GM, Tham WH, Fairhurst KJ, Yeo T, Fidock DA, Wittlin S, Chowdury M, de Koning-Ward TF, Chen G, Yan D, Charman SA, Baud D, Brand S, Jackson PF, Cowman AF, Gilson PR, Sleebs BE. Nguyen W, et al. Among authors: wittlin s. Eur J Med Chem. 2024 Apr 15;270:116354. doi: 10.1016/j.ejmech.2024.116354. Epub 2024 Mar 25. Eur J Med Chem. 2024. PMID: 38554474 Free article.
Post hoc analysis of food costs associated with Dietary Approaches to Stop Hypertension diet, whole food, plant-based diet, and typical baseline diet of individuals with insulin-treated type 2 diabetes mellitus in a nonrandomized crossover trial with meals provided.
Campbell EK, Taillie L, Blanchard LM, Wixom N, Harrington DK, Peterson DR, Wittlin SD, Campbell TM. Campbell EK, et al. Among authors: wittlin sd. Am J Clin Nutr. 2024 Mar;119(3):769-778. doi: 10.1016/j.ajcnut.2023.12.023. Epub 2023 Dec 30. Am J Clin Nutr. 2024. PMID: 38160802 Free article. Clinical Trial.
208 results