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Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function.
Coleman OD, Macdonald J, Thomson B, Ward JA, Stubbs CJ, McAllister TE, Clark S, Amin S, Cao Y, Abboud MI, Zhang Y, Sanganee H, Huber KVM, Claridge TDW, Kawamura A. Coleman OD, et al. Among authors: sanganee h. Chem Sci. 2023 Apr 17;14(26):7136-7146. doi: 10.1039/d2sc05944d. eCollection 2023 Jul 5. Chem Sci. 2023. PMID: 37416723 Free PMC article.
Rare variant associations with plasma protein levels in the UK Biobank.
Dhindsa RS, Burren OS, Sun BB, Prins BP, Matelska D, Wheeler E, Mitchell J, Oerton E, Hristova VA, Smith KR, Carss K, Wasilewski S, Harper AR, Paul DS, Fabre MA, Runz H, Viollet C, Challis B, Platt A; AstraZeneca Genomics Initiative; Vitsios D, Ashley EA, Whelan CD, Pangalos MN, Wang Q, Petrovski S. Dhindsa RS, et al. Nature. 2023 Oct;622(7982):339-347. doi: 10.1038/s41586-023-06547-x. Epub 2023 Oct 4. Nature. 2023. PMID: 37794183 Free PMC article.
Correction: Brüning-Richardson et al. GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models. Cancers 2021, 13, 5939.
Brüning-Richardson A, Shaw GC, Tams D, Brend T, Sanganee H, Barry ST, Hamm G, Goodwin RJA, Swales JG, King H, Steele L, Morton R, Widyadari A, Ward TA, Esteves F, Boissinot M, Mavria G, Droop A, Lawler SE, Short SC. Brüning-Richardson A, et al. Among authors: sanganee h. Cancers (Basel). 2022 Aug 4;14(15):3789. doi: 10.3390/cancers14153789. Cancers (Basel). 2022. PMID: 35954505 Free PMC article.
GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models.
Brüning-Richardson A, Shaw GC, Tams D, Brend T, Sanganee H, Barry ST, Hamm G, Goodwin RJA, Swales JG, King H, Steele L, Morton R, Widyadari A, Ward TA, Esteves F, Boissinot M, Mavria G, Droop A, Lawler SE, Short SC. Brüning-Richardson A, et al. Among authors: sanganee h. Cancers (Basel). 2021 Nov 25;13(23):5939. doi: 10.3390/cancers13235939. Cancers (Basel). 2021. PMID: 34885051 Free PMC article.
Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists.
Gardelli C, Wada H, Ray A, Caffrey M, Llinas A, Shamovsky I, Tholander J, Larsson J, Sivars U, Hultin L, Andersson U, Sanganee HJ, Stenvall K, Leidvik B, Gedda K, Jinton L, Rydén Landergren M, Karabelas K. Gardelli C, et al. Among authors: sanganee hj. J Med Chem. 2018 Jul 26;61(14):5974-5987. doi: 10.1021/acs.jmedchem.8b00322. Epub 2018 Jul 6. J Med Chem. 2018. PMID: 29909635
Potential strategies for increasing drug-discovery productivity.
Cumming JG, Finlay MR, Giordanetto F, Hemmerling M, Lister T, Sanganee H, Waring MJ. Cumming JG, et al. Among authors: sanganee h. Future Med Chem. 2014 Apr;6(5):515-27. doi: 10.4155/fmc.14.7. Future Med Chem. 2014. PMID: 24649955
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