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p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.
Circ Res. 2023 Jul 21;133(3):271-287. doi: 10.1161/CIRCRESAHA.121.320324. Epub 2023 Jul 6.
Circ Res. 2023.
PMID: 37409456
Coordination of endothelial cell positioning and fate specification by the epicardium.
Quijada P, Trembley MA, Misra A, Myers JA, Baker CD, Pérez-Hernández M, Myers JR, Dirkx RA Jr, Cohen ED, Delmar M, Ashton JM, Small EM.
Quijada P, et al. Among authors: dirkx ra jr.
Nat Commun. 2021 Jul 6;12(1):4155. doi: 10.1038/s41467-021-24414-z.
Nat Commun. 2021.
PMID: 34230480
Free PMC article.
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Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin.
Burke RM, Dirkx RA Jr, Quijada P, Lighthouse JK, Mohan A, O'Brien M, Wojciechowski W, Woeller CF, Phipps RP, Alexis JD, Ashton JM, Small EM.
Burke RM, et al. Among authors: dirkx ra jr.
Circ Res. 2021 May 28;128(11):1663-1678. doi: 10.1161/CIRCRESAHA.120.317791. Epub 2021 Apr 7.
Circ Res. 2021.
PMID: 33825488
Free PMC article.
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Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging.
Quijada P, Misra A, Velasquez LS, Burke RM, Lighthouse JK, Mickelsen DM, Dirkx RA Jr, Small EM.
Quijada P, et al. Among authors: dirkx ra jr.
J Mol Cell Cardiol. 2019 Apr;129:92-104. doi: 10.1016/j.yjmcc.2019.01.015. Epub 2019 Feb 13.
J Mol Cell Cardiol. 2019.
PMID: 30771308
Free PMC article.
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Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts.
Lighthouse JK, Burke RM, Velasquez LS, Dirkx RA Jr, Aiezza A 2nd, Moravec CS, Alexis JD, Rosenberg A, Small EM.
Lighthouse JK, et al. Among authors: dirkx ra jr.
JCI Insight. 2019 Jan 10;4(1):e92098. doi: 10.1172/jci.insight.92098.
JCI Insight. 2019.
PMID: 30626739
Free PMC article.
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Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.
Trembley MA, Quijada P, Agullo-Pascual E, Tylock KM, Colpan M, Dirkx RA Jr, Myers JR, Mickelsen DM, de Mesy Bentley K, Rothenberg E, Moravec CS, Alexis JD, Gregorio CC, Dirksen RT, Delmar M, Small EM.
Trembley MA, et al. Among authors: dirkx ra jr.
Circulation. 2018 Oct 23;138(17):1864-1878. doi: 10.1161/CIRCULATIONAHA.117.031788.
Circulation. 2018.
PMID: 29716942
Free PMC article.
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Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure.
Burke RM, Lighthouse JK, Quijada P, Dirkx RA Jr, Rosenberg A, Moravec CS, Alexis JD, Small EM.
Burke RM, et al. Among authors: dirkx ra jr.
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3436-E3445. doi: 10.1073/pnas.1717423115. Epub 2018 Mar 26.
Proc Natl Acad Sci U S A. 2018.
PMID: 29581288
Free PMC article.
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