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Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas.
J Immunother Cancer. 2023 Jun;11(6):e005584. doi: 10.1136/jitc-2022-005584.
J Immunother Cancer. 2023.
PMID: 37385724
Free PMC article.
Clinical Trial.
Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
Sun H, Cardinal KA, Wienkers L, Chin A, Kumar V, Neace C, Henderson C, Endres CJ, Topletz-Erickson A, Regal K, Vo A, Alley SC, Lee AJ.
Sun H, et al. Among authors: topletz erickson a.
Cancer Chemother Pharmacol. 2022 Jun;89(6):737-750. doi: 10.1007/s00280-022-04429-z. Epub 2022 Apr 18.
Cancer Chemother Pharmacol. 2022.
PMID: 35435471
Item in Clipboard
Evaluation of Safety and Clinically Relevant Drug-Drug Interactions with Tucatinib in Healthy Volunteers.
Topletz-Erickson A, Lee A, Rustia EL, Sun H, Mayor JG, Abdulrasool LI, Walker L, Endres CJ.
Topletz-Erickson A, et al.
Clin Pharmacokinet. 2022 Oct;61(10):1417-1426. doi: 10.1007/s40262-022-01144-z. Epub 2022 Aug 6.
Clin Pharmacokinet. 2022.
PMID: 35931943
Free PMC article.
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The Pharmacokinetics and Safety of Tucatinib in Volunteers with Hepatic Impairment.
Topletz-Erickson AR, Lee AJ, Mayor JG, Sun H, Abdulrasool LI, Rustia EL, Walker LN, Endres CJ.
Topletz-Erickson AR, et al.
Clin Pharmacokinet. 2022 Dec;61(12):1761-1770. doi: 10.1007/s40262-022-01183-6. Epub 2022 Dec 5.
Clin Pharmacokinet. 2022.
PMID: 36471222
Free PMC article.
Clinical Trial.
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Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib.
Templeton IE, Rowland-Yeo K, Jones HM, Endres CJ, Topletz-Erickson AR, Sun H, Lee AJ.
Templeton IE, et al. Among authors: topletz erickson ar.
Clin Pharmacol Ther. 2024 Feb;115(2):299-308. doi: 10.1002/cpt.3104. Epub 2023 Dec 8.
Clin Pharmacol Ther. 2024.
PMID: 37971208
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Effect of Tucatinib on Cardiac Repolarization in Healthy Volunteers.
Topletz-Erickson AR, Mayor JG, Liu HT, Abdulrasool LI, Endres CJ.
Topletz-Erickson AR, et al.
Drugs R D. 2023 Dec;23(4):411-419. doi: 10.1007/s40268-023-00440-8. Epub 2023 Sep 26.
Drugs R D. 2023.
PMID: 37751113
Free PMC article.
Clinical Trial.
Item in Clipboard
Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects.
Topletz-Erickson AR, Lee AJ, Mayor JG, Rustia EL, Abdulrasool LI, Wise AL, Dailey B, DeChenne S, Walker LN, Alley SC, Endres CJ.
Topletz-Erickson AR, et al.
J Clin Pharmacol. 2021 Apr;61(4):461-471. doi: 10.1002/jcph.1750. Epub 2020 Sep 28.
J Clin Pharmacol. 2021.
PMID: 32989831
Free PMC article.
Clinical Trial.
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