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Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas.
Coveler AL, Smith DC, Phillips T, Curti BD, Goel S, Mehta AN, Kuzel TM, Markovic SN, Rixe O, Bajor DL, Gajewski TF, Gutierrez M, Lee HJ, Gopal AK, Caimi P, Heath EI, Thompson JA, Ansari S, Jacquemont C, Topletz-Erickson A, Zhou P, Schmitt MW, Grilley-Olson JE. Coveler AL, et al. Among authors: topletz erickson a. J Immunother Cancer. 2023 Jun;11(6):e005584. doi: 10.1136/jitc-2022-005584. J Immunother Cancer. 2023. PMID: 37385724 Free PMC article. Clinical Trial.
Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
Sun H, Cardinal KA, Wienkers L, Chin A, Kumar V, Neace C, Henderson C, Endres CJ, Topletz-Erickson A, Regal K, Vo A, Alley SC, Lee AJ. Sun H, et al. Among authors: topletz erickson a. Cancer Chemother Pharmacol. 2022 Jun;89(6):737-750. doi: 10.1007/s00280-022-04429-z. Epub 2022 Apr 18. Cancer Chemother Pharmacol. 2022. PMID: 35435471
Effect of Tucatinib on Cardiac Repolarization in Healthy Volunteers.
Topletz-Erickson AR, Mayor JG, Liu HT, Abdulrasool LI, Endres CJ. Topletz-Erickson AR, et al. Drugs R D. 2023 Dec;23(4):411-419. doi: 10.1007/s40268-023-00440-8. Epub 2023 Sep 26. Drugs R D. 2023. PMID: 37751113 Free PMC article. Clinical Trial.