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Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex.
Sun Y, Baechler SA, Zhang X, Kumar S, Factor VM, Arakawa Y, Chau CH, Okamoto K, Parikh A, Walker B, Su YP, Chen J, Ting T, Huang SN, Beck E, Itkin Z, McKnight C, Xie C, Roper N, Nijhawan D, Figg WD, Meltzer PS, Yang JC, Thomas CJ, Pommier Y. Sun Y, et al. Among authors: chen j. Nat Commun. 2023 Jun 23;14(1):3762. doi: 10.1038/s41467-023-39374-9. Nat Commun. 2023. PMID: 37353483 Free PMC article.
Rapid image deconvolution and multiview fusion for optical microscopy.
Guo M, Li Y, Su Y, Lambert T, Nogare DD, Moyle MW, Duncan LH, Ikegami R, Santella A, Rey-Suarez I, Green D, Beiriger A, Chen J, Vishwasrao H, Ganesan S, Prince V, Waters JC, Annunziata CM, Hafner M, Mohler WA, Chitnis AB, Upadhyaya A, Usdin TB, Bao Z, Colón-Ramos D, La Riviere P, Liu H, Wu Y, Shroff H. Guo M, et al. Among authors: chen j. Nat Biotechnol. 2020 Nov;38(11):1337-1346. doi: 10.1038/s41587-020-0560-x. Epub 2020 Jun 29. Nat Biotechnol. 2020. PMID: 32601431 Free PMC article.
Multiview confocal super-resolution microscopy.
Wu Y, Han X, Su Y, Glidewell M, Daniels JS, Liu J, Sengupta T, Rey-Suarez I, Fischer R, Patel A, Combs C, Sun J, Wu X, Christensen R, Smith C, Bao L, Sun Y, Duncan LH, Chen J, Pommier Y, Shi YB, Murphy E, Roy S, Upadhyaya A, Colón-Ramos D, La Riviere P, Shroff H. Wu Y, et al. Among authors: chen j. Nature. 2021 Dec;600(7888):279-284. doi: 10.1038/s41586-021-04110-0. Epub 2021 Nov 26. Nature. 2021. PMID: 34837071 Free PMC article.
Incorporating the image formation process into deep learning improves network performance.
Li Y, Su Y, Guo M, Han X, Liu J, Vishwasrao HD, Li X, Christensen R, Sengupta T, Moyle MW, Rey-Suarez I, Chen J, Upadhyaya A, Usdin TB, Colón-Ramos DA, Liu H, Wu Y, Shroff H. Li Y, et al. Among authors: chen j. Nat Methods. 2022 Nov;19(11):1427-1437. doi: 10.1038/s41592-022-01652-7. Epub 2022 Oct 31. Nat Methods. 2022. PMID: 36316563 Free PMC article.
Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas.
Scheich S, Chen J, Liu J, Schnütgen F, Enssle JC, Ceribelli M, Thomas CJ, Choi J, Morris V, Hsiao T, Nguyen H, Wang B, Bolomsky A, Phelan JD, Corcoran S, Urlaub H, Young RM, Häupl B, Wright GW, Huang DW, Ji Y, Yu X, Xu W, Yang Y, Zhao H, Muppidi J, Pan KT, Oellerich T, Staudt LM. Scheich S, et al. Among authors: chen j. Cancer Discov. 2023 Aug 4;13(8):1862-1883. doi: 10.1158/2159-8290.CD-22-1401. Cancer Discov. 2023. PMID: 37141112 Free PMC article.
Single-shot super-resolution total internal reflection fluorescence microscopy.
Guo M, Chandris P, Giannini JP, Trexler AJ, Fischer R, Chen J, Vishwasrao HD, Rey-Suarez I, Wu Y, Wu X, Waterman CM, Patterson GH, Upadhyaya A, Taraska JW, Shroff H. Guo M, et al. Among authors: chen j. Nat Methods. 2018 Jun;15(6):425-428. doi: 10.1038/s41592-018-0004-4. Epub 2018 May 7. Nat Methods. 2018. PMID: 29735999 Free PMC article.
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