Todd PK - Search Results

1

Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS.

Malik I, Tseng YJ, Wieland CM, Green KM, Zheng K, Calleja K, Todd PK. Malik I, et al. Among authors: todd pk. Neurobiol Dis. 2023 Aug;184:106212. doi: 10.1016/j.nbd.2023.106212. Epub 2023 Jun 22. Neurobiol Dis. 2023. PMID: 37352983 Free article.

2

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins.

Kearse MG, Green KM, Krans A, Rodriguez CM, Linsalata AE, Goldstrohm AC, Todd PK. Kearse MG, et al. Among authors: todd pk. Mol Cell. 2016 Apr 21;62(2):314-322. doi: 10.1016/j.molcel.2016.02.034. Epub 2016 Mar 31. Mol Cell. 2016. PMID: 27041225 Free PMC article.

3

RAN translation-What makes it run?

Green KM, Linsalata AE, Todd PK. Green KM, et al. Among authors: todd pk. Brain Res. 2016 Sep 15;1647:30-42. doi: 10.1016/j.brainres.2016.04.003. Epub 2016 Apr 6. Brain Res. 2016. PMID: 27060770 Free PMC article. Review.

4

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response.

Green KM, Glineburg MR, Kearse MG, Flores BN, Linsalata AE, Fedak SJ, Goldstrohm AC, Barmada SJ, Todd PK. Green KM, et al. Among authors: todd pk. Nat Commun. 2017 Dec 8;8(1):2005. doi: 10.1038/s41467-017-02200-0. Nat Commun. 2017. PMID: 29222490 Free PMC article.

5

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors.

Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE. Kearse MG, et al. Among authors: todd pk. Genes Dev. 2019 Jul 1;33(13-14):871-885. doi: 10.1101/gad.324715.119. Epub 2019 Jun 6. Genes Dev. 2019. PMID: 31171704 Free PMC article.

6

New pathologic mechanisms in nucleotide repeat expansion disorders.

Rodriguez CM, Todd PK. Rodriguez CM, et al. Among authors: todd pk. Neurobiol Dis. 2019 Oct;130:104515. doi: 10.1016/j.nbd.2019.104515. Epub 2019 Jun 21. Neurobiol Dis. 2019. PMID: 31229686 Free PMC article. Review.

7

DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation.

Linsalata AE, He F, Malik AM, Glineburg MR, Green KM, Natla S, Flores BN, Krans A, Archbold HC, Fedak SJ, Barmada SJ, Todd PK. Linsalata AE, et al. Among authors: todd pk. EMBO Rep. 2019 Sep;20(9):e47498. doi: 10.15252/embr.201847498. Epub 2019 Jul 25. EMBO Rep. 2019. PMID: 31347257 Free PMC article.

8

High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation.

Green KM, Sheth UJ, Flores BN, Wright SE, Sutter AB, Kearse MG, Barmada SJ, Ivanova MI, Todd PK. Green KM, et al. Among authors: todd pk. J Biol Chem. 2019 Dec 6;294(49):18624-18638. doi: 10.1074/jbc.RA119.009951. Epub 2019 Oct 23. J Biol Chem. 2019. PMID: 31649034 Free PMC article.

9

Molecular mechanisms underlying nucleotide repeat expansion disorders.

Malik I, Kelley CP, Wang ET, Todd PK. Malik I, et al. Among authors: todd pk. Nat Rev Mol Cell Biol. 2021 Sep;22(9):589-607. doi: 10.1038/s41580-021-00382-6. Epub 2021 Jun 17. Nat Rev Mol Cell Biol. 2021. PMID: 34140671 Free PMC article. Review.

10

The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation.

Tseng YJ, Sandwith SN, Green KM, Chambers AE, Krans A, Raimer HM, Sharlow ME, Reisinger MA, Richardson AE, Routh ED, Smaldino MA, Wang YH, Vaughn JP, Todd PK, Smaldino PJ. Tseng YJ, et al. Among authors: todd pk. J Biol Chem. 2021 Aug;297(2):100914. doi: 10.1016/j.jbc.2021.100914. Epub 2021 Jun 24. J Biol Chem. 2021. PMID: 34174288 Free PMC article.

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