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Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists.
Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P. Liu H, et al. Among authors: liu x. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12046-12050. doi: 10.1073/pnas.1813988115. Epub 2018 Nov 7. Proc Natl Acad Sci U S A. 2018. PMID: 30404914 Free PMC article.
Structural Insights into the Process of GPCR-G Protein Complex Formation.
Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixà-González R, Mathiesen JM, Hildebrand PW, Kobilka BK. Liu X, et al. Among authors: liu h. Cell. 2019 May 16;177(5):1243-1251.e12. doi: 10.1016/j.cell.2019.04.021. Epub 2019 May 9. Cell. 2019. PMID: 31080070 Free PMC article.
Mechanism of β2AR regulation by an intracellular positive allosteric modulator.
Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Liu X, et al. Science. 2019 Jun 28;364(6447):1283-1287. doi: 10.1126/science.aaw8981. Epub 2019 Jun 27. Science. 2019. PMID: 31249059 Free PMC article.
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor.
Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P. Liu X, et al. Nat Chem Biol. 2020 Jul;16(7):749-755. doi: 10.1038/s41589-020-0549-2. Epub 2020 Jun 1. Nat Chem Biol. 2020. PMID: 32483378 Free PMC article.
Analysis of β2AR-Gs and β2AR-Gi complex formation by NMR spectroscopy.
Ma X, Hu Y, Batebi H, Heng J, Xu J, Liu X, Niu X, Li H, Hildebrand PW, Jin C, Kobilka BK. Ma X, et al. Among authors: liu x. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):23096-23105. doi: 10.1073/pnas.2009786117. Epub 2020 Aug 31. Proc Natl Acad Sci U S A. 2020. PMID: 32868434 Free PMC article.
126,145 results
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