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Ganaplacide (KAF156) plus lumefantrine solid dispersion formulation combination for uncomplicated Plasmodium falciparum malaria: an open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial.
Lancet Infect Dis. 2023 Sep;23(9):1051-1061. doi: 10.1016/S1473-3099(23)00209-8. Epub 2023 Jun 13.
Lancet Infect Dis. 2023.
PMID: 37327809
Clinical Trial.
Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria.
Gansane A, Lingani M, Yeka A, Nahum A, Bouyou-Akotet M, Mombo-Ngoma G, Kaguthi G, Barceló C, Laurijssens B, Cantalloube C, Macintyre F, Djeriou E, Jessel A, Bejuit R, Demarest H, Marrast AC, Debe S, Tinto H, Kibuuka A, Nahum D, Mawili-Mboumba DP, Zoleko-Manego R, Mugenya I, Olewe F, Duparc S, Ogutu B.
Gansane A, et al. Among authors: kibuuka a.
Malar J. 2023 Jan 3;22(1):2. doi: 10.1186/s12936-022-04420-2.
Malar J. 2023.
PMID: 36597076
Free PMC article.
Clinical Trial.
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A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.
Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H; FALCI Study Group.
Adoke Y, et al. Among authors: kibuuka a.
Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4.
Malar J. 2021.
PMID: 34011358
Free PMC article.
Clinical Trial.
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A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria.
Macintyre F, Adoke Y, Tiono AB, Duong TT, Mombo-Ngoma G, Bouyou-Akotet M, Tinto H, Bassat Q, Issifou S, Adamy M, Demarest H, Duparc S, Leroy D, Laurijssens BE, Biguenet S, Kibuuka A, Tshefu AK, Smith M, Foster C, Leipoldt I, Kremsner PG, Phuc BQ, Ouedraogo A, Ramharter M; OZ-Piperaquine Study Group.
Macintyre F, et al. Among authors: kibuuka a.
BMC Med. 2017 Oct 9;15(1):181. doi: 10.1186/s12916-017-0940-3.
BMC Med. 2017.
PMID: 28988541
Free PMC article.
Clinical Trial.
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Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children.
Yeka A, Wallender E, Mulebeke R, Kibuuka A, Kigozi R, Bosco A, Kyambadde P, Opigo J, Kalyesubula S, Senzoga J, Vinden J, Conrad M, Rosenthal PJ.
Yeka A, et al. Among authors: kibuuka a.
J Infect Dis. 2019 Mar 15;219(7):1112-1120. doi: 10.1093/infdis/jiy637.
J Infect Dis. 2019.
PMID: 30418593
Free PMC article.
Clinical Trial.
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A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial.
Four Artemisinin-Based Combinations (4ABC) Study Group.
Four Artemisinin-Based Combinations (4ABC) Study Group.
PLoS Med. 2011 Nov;8(11):e1001119. doi: 10.1371/journal.pmed.1001119. Epub 2011 Nov 8.
PLoS Med. 2011.
PMID: 22087077
Free PMC article.
Clinical Trial.
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Bacteremia Among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test.
Kibuuka A, Byakika-Kibwika P, Achan J, Yeka A, Nalyazi JN, Mpimbaza A, Rosenthal PJ, Kamya MR.
Kibuuka A, et al.
Am J Trop Med Hyg. 2015 Aug;93(2):276-280. doi: 10.4269/ajtmh.14-0494. Epub 2015 Jun 8.
Am J Trop Med Hyg. 2015.
PMID: 26055736
Free PMC article.
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