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14 results

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Page 1
Ganaplacide (KAF156) plus lumefantrine solid dispersion formulation combination for uncomplicated Plasmodium falciparum malaria: an open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial.
Ogutu B, Yeka A, Kusemererwa S, Thompson R, Tinto H, Toure AO, Uthaisin C, Verma A, Kibuuka A, Lingani M, Lourenço C, Mombo-Ngoma G, Nduba V, N'Guessan TL, Nassa GJW, Nyantaro M, Tina LO, Singh PK, El Gaaloul M, Marrast AC, Chikoto H, Csermak K, Demin I, Mehta D, Pathan R, Risterucci C, Su G, Winnips C, Kaguthi G, Fofana B, Grobusch MP. Ogutu B, et al. Among authors: el gaaloul m. Lancet Infect Dis. 2023 Sep;23(9):1051-1061. doi: 10.1016/S1473-3099(23)00209-8. Epub 2023 Jun 13. Lancet Infect Dis. 2023. PMID: 37327809 Clinical Trial.
Evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women: protocol of a multicentre, two-arm, randomised, placebo-controlled, superiority clinical trial (MAMAH project).
González R, Nhampossa T, Mombo-Ngoma G, Mischlinger J, Esen M, Tchouatieu AM, Pons-Duran C, Dimessa LB, Lell B, Lagler H, Garcia-Otero L, Zoleko Manego R, El Gaaloul M, Sanz S, Piqueras M, Sevene E, Ramharter M, Saute F, Menendez C. González R, et al. Among authors: el gaaloul m. BMJ Open. 2021 Nov 23;11(11):e053197. doi: 10.1136/bmjopen-2021-053197. BMJ Open. 2021. PMID: 34815285 Free PMC article.
Safety, Tolerability, and Parasite Clearance Kinetics in Controlled Human Malaria Infection after Direct Venous Inoculation of Plasmodium falciparum Sporozoites: A Model for Evaluating New Blood-Stage Antimalarial Drugs.
Chughlay MF, Chalon S, El Gaaloul M, Gobeau N, Möhrle JJ, Berghmans PJ, Van Leuven K, Marx MW, Rosanas-Urgell A, Flynn J, Escoffier E, Izquierdo-Juncàs D, Jansen B, Mitov V, Kümmel A, Van Geertruyden JP, Barnes KI. Chughlay MF, et al. Among authors: el gaaloul m. Am J Trop Med Hyg. 2022 Aug 29;107(4):804-814. doi: 10.4269/ajtmh.21-1297. Print 2022 Oct 12. Am J Trop Med Hyg. 2022. PMID: 36037868 Free PMC article. Clinical Trial.
Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study.
Chughlay MF, El Gaaloul M, Donini C, Campo B, Berghmans PJ, Lucardie A, Marx MW, Cherkaoui-Rbati MH, Langdon G, Angulo-Barturen I, Viera S, Rosanas-Urgell A, Van Geertruyden JP, Chalon S. Chughlay MF, et al. Among authors: el gaaloul m. Am J Trop Med Hyg. 2021 Feb 8;104(4):1348-1358. doi: 10.4269/ajtmh.20-1165. Am J Trop Med Hyg. 2021. PMID: 33556040 Free PMC article.
Concentration-QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers.
Täubel J, Lorch U, Ferber G, Spencer CS, Freier A, Coates S, El Gaaloul M, Donini C, Chughlay MF, Chalon S. Täubel J, et al. Among authors: el gaaloul m. Br J Clin Pharmacol. 2022 Jan;88(1):128-137. doi: 10.1111/bcp.14933. Epub 2021 Jul 9. Br J Clin Pharmacol. 2022. PMID: 34075612 Free PMC article. Clinical Trial.
First-in-human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection.
Chughlay MF, Rossignol E, Donini C, El Gaaloul M, Lorch U, Coates S, Langdon G, Hammond T, Möhrle J, Chalon S. Chughlay MF, et al. Among authors: el gaaloul m. Br J Clin Pharmacol. 2020 Jun;86(6):1113-1124. doi: 10.1111/bcp.14219. Epub 2020 Feb 12. Br J Clin Pharmacol. 2020. PMID: 31925817 Free PMC article. Clinical Trial.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Chughlay MF, Barnes KI, El Gaaloul M, Abla N, Möhrle JJ, Griffin P, van Giersbergen P, Reuter SE, Schultz HB, Kress A, Tapley P, Webster RA, Wells T, McCarthy JS, Barber BE, Marquart L, Boyle MJ, Engwerda CR, Chalon S. Chughlay MF, et al. Among authors: el gaaloul m. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0158421. doi: 10.1128/AAC.01584-21. Epub 2021 Oct 25. Antimicrob Agents Chemother. 2022. PMID: 34694880 Free PMC article. Clinical Trial.
Safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnant women with HIV from Gabon and Mozambique: a randomised, double-blind, placebo-controlled trial.
González R, Nhampossa T, Mombo-Ngoma G, Mischlinger J, Esen M, Tchouatieu AM, Mendes A, Figueroa-Romero A, Zoleko-Manego R, Lell B, Lagler H, Stoeger L, Dimessa LB, El Gaaloul M, Sanz S, Méndez S, Piqueras M, Sevene E, Ramharter M, Saúte F, Menendez C; MAMAH study group. González R, et al. Among authors: el gaaloul m. Lancet Infect Dis. 2024 May;24(5):476-487. doi: 10.1016/S1473-3099(23)00738-7. Epub 2024 Jan 12. Lancet Infect Dis. 2024. PMID: 38224706 Clinical Trial.
14 results