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Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires.
Philippon C, Tao S, Clement D, Haroun-Izquierdo A, Kichula KM, Netskar H, Brandt L, Oei VS, Kanaya M, Lanuza PM, Schaffer M, Goodridge JP, Horowitz A, Zhu F, Hammer Q, Sohlberg E, Majhi RK, Kveberg L, Önfelt B, Norman PJ, Malmberg KJ. Philippon C, et al. Among authors: norman pj. Blood Adv. 2023 Aug 22;7(16):4492-4504. doi: 10.1182/bloodadvances.2023009827. Blood Adv. 2023. PMID: 37327114 Free PMC article.
Donor KIR2DL1 Allelic Polymorphism Influences Posthematopoietic Progenitor Cell Transplantation Outcomes in the T Cell Depleted and Reduced Intensity Conditioning Setting.
Wright PA, van de Pasch LAL, Dignan FL, Kichula KM, Pollock NR, Norman PJ, Marchan E, Hill L, Vandelbosch S, Fullwood C, Sheldon S, Hampson L, Tholouli E, Poulton KV. Wright PA, et al. Among authors: norman pj. Transplant Cell Ther. 2024 May;30(5):488.e1-488.e15. doi: 10.1016/j.jtct.2024.02.014. Epub 2024 Feb 17. Transplant Cell Ther. 2024. PMID: 38369017
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males.
Croci S, Venneri MA, Mantovani S, Fallerini C, Benetti E, Picchiotti N, Campolo F, Imperatore F, Palmieri M, Daga S, Gabbi C, Montagnani F, Beligni G, Farias TDJ, Carriero ML, Di Sarno L, Alaverdian D, Aslaksen S, Cubellis MV, Spiga O, Baldassarri M, Fava F, Norman PJ, Frullanti E, Isidori AM, Amoroso A, Mari F, Furini S, Mondelli MU, Gen-Covid Multicenter Study, Chiariello M, Renieri A, Meloni I. Croci S, et al. Among authors: norman pj. Autophagy. 2022 Jul;18(7):1662-1672. doi: 10.1080/15548627.2021.1995152. Epub 2021 Dec 29. Autophagy. 2022. PMID: 34964709 Free PMC article.
HLA-DPB1*13:01 associates with enhanced, and KIR2DS4*001 with diminished protection from developing severe COVID-19.
Farias TDJ, Brugiapaglia S, Croci S, Magistroni P, Curcio C, Zguro K, Fallerini C, Fava F, Pettini F, Kichula KM, Pollock NR, Font-Porterias N, Palmer WH, Marin WM, Baldassarri M, Bruttini M, Hollenbach JA, Hendricks AE, Meloni I, Novelli F; GEN-COVID Multicenter Study Group; Renieri A, Furini S, Norman PJ, Amoroso A. Farias TDJ, et al. Among authors: norman pj. HLA. 2024 Jan;103(1):e15251. doi: 10.1111/tan.15251. Epub 2023 Oct 18. HLA. 2024. PMID: 37850268 Free article.
Exceptional diversity of KIR and HLA class I in Egypt.
Montero-Martin G, Kichula KM, Misra MK, de Brito Vargas L, Marin WM, Hollenbach JA, Fernández-Viña MA, Elfishawi S, Norman PJ. Montero-Martin G, et al. Among authors: norman pj. HLA. 2024 Jan;103(1):e15177. doi: 10.1111/tan.15177. Epub 2023 Aug 2. HLA. 2024. PMID: 37528739
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.
Palmer WH, Leaton LA, Campos Codo A, Crute B, Roest J, Zhu S, Petersen J, Tobin RP, Hume PS, Stone M, van Bokhoven A, Gerich ME, McCarter MD, Zhu Y, Janssen WJ, Vivian JP, Trowsdale J, Getahun A, Rossjohn J, Cambier J, Loh L, Norman PJ. Palmer WH, et al. Among authors: norman pj. Sci Immunol. 2023 Jun 30;8(84):eade5343. doi: 10.1126/sciimmunol.ade5343. Epub 2023 Jun 30. Sci Immunol. 2023. PMID: 37390222
117 results