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Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology.
Manfredsson FP, Luk KC, Benskey MJ, Gezer A, Garcia J, Kuhn NC, Sandoval IM, Patterson JR, O'Mara A, Yonkers R, Kordower JH. Manfredsson FP, et al. Among authors: luk kc. Neurobiol Dis. 2018 Apr;112:106-118. doi: 10.1016/j.nbd.2018.01.008. Epub 2018 Jan 16. Neurobiol Dis. 2018. PMID: 29341898 Free PMC article.
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.
Patterson JR, Duffy MF, Kemp CJ, Howe JW, Collier TJ, Stoll AC, Miller KM, Patel P, Levine N, Moore DJ, Luk KC, Fleming SM, Kanaan NM, Paumier KL, El-Agnaf OMA, Sortwell CE. Patterson JR, et al. Among authors: luk kc. Neurobiol Dis. 2019 Oct;130:104525. doi: 10.1016/j.nbd.2019.104525. Epub 2019 Jul 2. Neurobiol Dis. 2019. PMID: 31276792 Free PMC article.
Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.
Henderson MX, Covell DJ, Chung CH, Pitkin RM, Sandler RM, Decker SC, Riddle DM, Zhang B, Gathagan RJ, James MJ, Trojanowski JQ, Brunden KR, Lee VMY, Luk KC. Henderson MX, et al. Among authors: luk kc. Neurobiol Dis. 2020 Mar;136:104712. doi: 10.1016/j.nbd.2019.104712. Epub 2019 Dec 16. Neurobiol Dis. 2020. PMID: 31837422 Free PMC article.
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.
Gezer AO, Kochmanski J, VanOeveren SE, Cole-Strauss A, Kemp CJ, Patterson JR, Miller KM, Kuhn NC, Herman DE, McIntire A, Lipton JW, Luk KC, Fleming SM, Sortwell CE, Bernstein AI. Gezer AO, et al. Among authors: luk kc. Neurobiol Dis. 2020 Jul;141:104947. doi: 10.1016/j.nbd.2020.104947. Epub 2020 May 15. Neurobiol Dis. 2020. PMID: 32422283 Free PMC article.
Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy.
Bhatia TN, Clark RN, Needham PG, Miner KM, Jamenis AS, Eckhoff EA, Abraham N, Hu X, Wipf P, Luk KC, Brodsky JL, Leak RK. Bhatia TN, et al. Among authors: luk kc. Neurotherapeutics. 2021 Oct;18(4):2541-2564. doi: 10.1007/s13311-021-01114-6. Epub 2021 Sep 15. Neurotherapeutics. 2021. PMID: 34528172 Free PMC article.
172 results