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The new quinazoline derivative (N2-methyl-N4-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats.
Eur J Pharmacol. 2023 Aug 15;953:175829. doi: 10.1016/j.ejphar.2023.175829. Epub 2023 Jun 10.
Eur J Pharmacol. 2023.
PMID: 37307938
Quinazoline-based human phosphodiesterase 5 inhibitors exhibited a selective vasorelaxant effect on rat isolated pulmonary arteries involving NO-sGC-cGMP pathway and calcium inhibitory effects.
Chatturong U, Martin H, Totoson P, Ingkaninan K, Temkitthawon P, Sermsenaphorn S, Somarin T, Konsue A, Gleeson MP, Demougeot C, Chootip K.
Chatturong U, et al. Among authors: sermsenaphorn s.
Vascul Pharmacol. 2022 Dec;147:107111. doi: 10.1016/j.vph.2022.107111. Epub 2022 Sep 24.
Vascul Pharmacol. 2022.
PMID: 36162651
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