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Discovery of highly potent human deoxyuridine triphosphatase inhibitors based on the conformation restriction strategy.
Miyahara S, Miyakoshi H, Yokogawa T, Chong KT, Taguchi J, Muto T, Endoh K, Yano W, Wakasa T, Ueno H, Takao Y, Fujioka A, Hashimoto A, Itou K, Yamamura K, Nomura M, Nagasawa H, Shuto S, Fukuoka M. Miyahara S, et al. Among authors: muto t. J Med Chem. 2012 Jun 14;55(11):5483-96. doi: 10.1021/jm300416h. Epub 2012 May 30. J Med Chem. 2012. PMID: 22607122
1,2,3-Triazole-containing uracil derivatives with excellent pharmacokinetics as a novel class of potent human deoxyuridine triphosphatase inhibitors.
Miyakoshi H, Miyahara S, Yokogawa T, Endoh K, Muto T, Yano W, Wakasa T, Ueno H, Chong KT, Taguchi J, Nomura M, Takao Y, Fujioka A, Hashimoto A, Itou K, Yamamura K, Shuto S, Nagasawa H, Fukuoka M. Miyakoshi H, et al. Among authors: muto t. J Med Chem. 2012 Jul 26;55(14):6427-37. doi: 10.1021/jm3004174. Epub 2012 Jul 3. J Med Chem. 2012. PMID: 22715973
Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors.
Miyahara S, Miyakoshi H, Yokogawa T, Chong KT, Taguchi J, Muto T, Endoh K, Yano W, Wakasa T, Ueno H, Takao Y, Fujioka A, Hashimoto A, Itou K, Yamamura K, Nomura M, Nagasawa H, Shuto S, Fukuoka M. Miyahara S, et al. Among authors: muto t. J Med Chem. 2012 Apr 12;55(7):2970-80. doi: 10.1021/jm201628y. Epub 2012 Mar 26. J Med Chem. 2012. PMID: 22339362
Detection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry.
Ishii A, Tsukamoto S, Mimura N, Miyamoto-Nagai Y, Isshiki Y, Matsui S, Nakao S, Shibamiya A, Hino Y, Kayamori K, Oshima-Hasegawa N, Muto T, Takeda Y, Suichi T, Misawa S, Ohwada C, Yokote K, Kuwabara S, Nakaseko C, Takamatsu H, Sakaida E. Ishii A, et al. Among authors: muto t. Sci Rep. 2024 May 6;14(1):10362. doi: 10.1038/s41598-024-61034-1. Sci Rep. 2024. PMID: 38710832 Free PMC article.
Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression.
Matsui S, Ri C, Bolanos LC, Choi K, Shibamiya A, Ishii A, Takaishi K, Oshima-Hasegawa N, Tsukamoto S, Takeda Y, Mimura N, Yoshimi A, Yokote K, Starczynowski DT, Sakaida E, Muto T. Matsui S, et al. Among authors: muto t. Leukemia. 2024 May;38(5):1032-1045. doi: 10.1038/s41375-024-02245-3. Epub 2024 Apr 12. Leukemia. 2024. PMID: 38609495 Free PMC article.
1,259 results