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EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta.
Geisler HC, Ghalsasi AA, Safford HC, Swingle KL, Thatte AS, Mukalel AJ, Gong N, Hamilton AG, Han EL, Nachod BE, Padilla MS, Mitchell MJ. Geisler HC, et al. Among authors: mitchell mj. J Control Release. 2024 May 21:S0168-3659(24)00320-1. doi: 10.1016/j.jconrel.2024.05.036. Online ahead of print. J Control Release. 2024. PMID: 38789090
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions.
Anchordoquy T, Artzi N, Balyasnikova IV, Barenholz Y, La-Beck NM, Brenner JS, Chan WCW, Decuzzi P, Exner AA, Gabizon A, Godin B, Lai SK, Lammers T, Mitchell MJ, Moghimi SM, Muzykantov VR, Peer D, Nguyen J, Popovtzer R, Ricco M, Serkova NJ, Singh R, Schroeder A, Schwendeman AA, Straehla JP, Teesalu T, Tilden S, Simberg D. Anchordoquy T, et al. Among authors: mitchell mj. ACS Nano. 2024 Jun 4;18(22):13983-13999. doi: 10.1021/acsnano.4c00182. Epub 2024 May 20. ACS Nano. 2024. PMID: 38767983 Review.
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation.
Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. Zhao G, et al. Among authors: mitchell mj. Nat Commun. 2024 May 18;15(1):4235. doi: 10.1038/s41467-024-48589-3. Nat Commun. 2024. PMID: 38762489 Free PMC article.
Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression.
da Silva WN, Carvalho Costa PA, Scalzo Júnior SRA, Ferreira HAS, Prazeres PHDM, Campos CLV, Rodrigues Alves MT, Alves da Silva NJ, de Castro Santos AL, Guimarães LC, Chen Ferris ME, Thatte A, Hamilton A, Bicalho KA, Lobo AO, Santiago HDC, da Silva Barcelos L, Figueiredo MM, Teixeira MM, Vasconcelos Costa V, Mitchell MJ, Frézard F, Pires Goulart Guimaraes P. da Silva WN, et al. Among authors: mitchell mj. Int J Nanomedicine. 2024 Mar 14;19:2655-2673. doi: 10.2147/IJN.S452896. eCollection 2024. Int J Nanomedicine. 2024. PMID: 38500680 Free PMC article.
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models.
Xue L, Hamilton AG, Zhao G, Xiao Z, El-Mayta R, Han X, Gong N, Xiong X, Xu J, Figueroa-Espada CG, Shepherd SJ, Mukalel AJ, Alameh MG, Cui J, Wang K, Vaughan AE, Weissman D, Mitchell MJ. Xue L, et al. Among authors: mitchell mj. Nat Commun. 2024 Feb 29;15(1):1884. doi: 10.1038/s41467-024-45422-9. Nat Commun. 2024. PMID: 38424061 Free PMC article.
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy.
Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Metzloff AE, et al. Among authors: mitchell mj. Adv Mater. 2024 Feb 28:e2313226. doi: 10.1002/adma.202313226. Online ahead of print. Adv Mater. 2024. PMID: 38419362
353 results