Inoue A - Search Results

1

Class B1 GPCR activation by an intracellular agonist.

Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O. Kobayashi K, et al. Among authors: inoue a. Nature. 2023 Jun;618(7967):1085-1093. doi: 10.1038/s41586-023-06169-3. Epub 2023 Jun 7. Nature. 2023. PMID: 37286611 Free PMC article.

2

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators.

Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O. Nishimasu H, et al. Among authors: inoue a. Nat Struct Mol Biol. 2011 Feb;18(2):205-12. doi: 10.1038/nsmb.1998. Epub 2011 Jan 16. Nat Struct Mol Biol. 2011. PMID: 21240269

3

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation.

Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A, Higashiyama S, Ohwada T, Arai H, Makide K, Aoki J. Inoue A, et al. Nat Methods. 2012 Oct;9(10):1021-9. doi: 10.1038/nmeth.2172. Epub 2012 Sep 16. Nat Methods. 2012. PMID: 22983457

4

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Cahill TJ 3rd, et al. Among authors: inoue a. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21. Proc Natl Acad Sci U S A. 2017. PMID: 28223524 Free PMC article.

5

Genetic evidence that β-arrestins are dispensable for the initiation of β₂-adrenergic receptor signaling to ERK.

O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS. O'Hayre M, et al. Among authors: inoue a. Sci Signal. 2017 Jun 20;10(484):eaal3395. doi: 10.1126/scisignal.aal3395. Sci Signal. 2017. PMID: 28634209 Free PMC article.

6

Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA₆.

Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O. Taniguchi R, et al. Among authors: inoue a. Nature. 2017 Aug 17;548(7667):356-360. doi: 10.1038/nature23448. Epub 2017 Aug 9. Nature. 2017. PMID: 28792932

7

X-ray structures of endothelin ET_B receptor bound to clinical antagonist bosentan and its analog.

Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O. Shihoya W, et al. Among authors: inoue a. Nat Struct Mol Biol. 2017 Sep;24(9):758-764. doi: 10.1038/nsmb.3450. Epub 2017 Aug 14. Nat Struct Mol Biol. 2017. PMID: 28805809

8

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias.

Sergeev E, Hansen AH, Bolognini D, Kawakami K, Kishi T, Aoki J, Ulven T, Inoue A, Hudson BD, Milligan G. Sergeev E, et al. Among authors: inoue a. Sci Rep. 2017 Oct 23;7(1):13741. doi: 10.1038/s41598-017-14096-3. Sci Rep. 2017. PMID: 29061999 Free PMC article.

9

Lack of beta-arrestin signaling in the absence of active G proteins.

Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E. Grundmann M, et al. Among authors: inoue a. Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3. Nat Commun. 2018. PMID: 29362459 Free PMC article.

10

Crystal structures of human ET_B receptor provide mechanistic insight into receptor activation and partial activation.

Shihoya W, Izume T, Inoue A, Yamashita K, Kadji FMN, Hirata K, Aoki J, Nishizawa T, Nureki O. Shihoya W, et al. Among authors: inoue a. Nat Commun. 2018 Nov 9;9(1):4711. doi: 10.1038/s41467-018-07094-0. Nat Commun. 2018. PMID: 30413709 Free PMC article.

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