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Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results.
Yap TA, Fontana E, Lee EK, Spigel DR, Højgaard M, Lheureux S, Mettu NB, Carneiro BA, Carter L, Plummer R, Cote GM, Meric-Bernstam F, O'Connell J, Schonhoft JD, Wainszelbaum M, Fretland AJ, Manley P, Xu Y, Ulanet D, Rimkunas V, Zinda M, Koehler M, Silverman IM, Reis-Filho JS, Rosen E. Yap TA, et al. Among authors: fretland aj. Nat Med. 2023 Jun;29(6):1400-1411. doi: 10.1038/s41591-023-02399-0. Epub 2023 Jun 5. Nat Med. 2023. PMID: 37277454 Free PMC article. Clinical Trial.
Development of a Practical Nomogram for Personalized Anemia Management in Patients Treated with Ataxia Telangiectasia and Rad3-related Inhibitor Camonsertib.
Rosen E, Yap TA, Lee EK, Højgaard M, Mettu NB, Lheureux S, Carneiro BA, Plummer R, Fretland AJ, Ulanet D, Xu Y, McDougall R, Koehler M, Fontana E. Rosen E, et al. Among authors: fretland aj. Clin Cancer Res. 2024 Feb 16;30(4):687-694. doi: 10.1158/1078-0432.CCR-23-2080. Clin Cancer Res. 2024. PMID: 38078898 Free PMC article.
ATR inhibitor, camonsertib, dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study).
Fontana E, Rosen E, Lee EK, Højgaard M, Mettu NB, Lheureux S, Carneiro BA, Cote GM, Carter L, Plummer R, Mahalingam D, Fretland AJ, Schonhoft JD, Silverman IM, Wainszelbaum M, Xu Y, Ulanet D, Koehler M, Yap TA. Fontana E, et al. Among authors: fretland aj. J Natl Cancer Inst. 2024 May 6:djae098. doi: 10.1093/jnci/djae098. Online ahead of print. J Natl Cancer Inst. 2024. PMID: 38710487
Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib.
Papp R, Trimble L, Fretland AJ, Manohar R, Phipps R, Kvaerno L, Perryman AL, Reynolds G, Black WC. Papp R, et al. Among authors: fretland aj. Drug Metab Dispos. 2024 Feb 20:DMD-AR-2023-001611. doi: 10.1124/dmd.123.001611. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38378703 Free article.
Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes.
Vasalou C, Ferguson D, Li W, Muse V, Gibbons FD, Sonzini S, Zhang G, Pop-Damkov P, Gangl E, Balachander SB, Wen S, Schuller AG, Puri S, Mazza M, Ashford M, Fretland AJ, McGinnity DF, Jones RDO. Vasalou C, et al. Among authors: fretland aj. Mol Pharm. 2022 Jan 3;19(1):172-187. doi: 10.1021/acs.molpharmaceut.1c00715. Epub 2021 Dec 10. Mol Pharm. 2022. PMID: 34890209
Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors.
Pilla Reddy V, Fretland AJ, Zhou D, Sharma S, Chen B, Vishwanathan K, McGinnity DF, Xu Y, Ware JA. Pilla Reddy V, et al. Among authors: fretland aj. Cancer Chemother Pharmacol. 2021 Sep;88(3):451-464. doi: 10.1007/s00280-021-04302-5. Epub 2021 Jun 2. Cancer Chemother Pharmacol. 2021. PMID: 34080039 Free PMC article.
Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl-1 Inhibitor AZD5991.
Goliaei A, Woods HA, Tron AE, Belmonte MA, Secrist JP, Ferguson D, Drew L, Fretland AJ, Aldridge BB, Gibbons FD. Goliaei A, et al. Among authors: fretland aj. CPT Pharmacometrics Syst Pharmacol. 2020 Oct;9(10):561-570. doi: 10.1002/psp4.12552. Epub 2020 Sep 17. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32860732 Free PMC article.
50 results