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Page 1
Inspired by Nature: Isostere Concepts in Plant Hormone Chemistry.
Frackenpohl J, Abel SAG, Alnafta N, Barber DM, Bojack G, Brant NZ, Helmke H, Mattison RL. Frackenpohl J, et al. Among authors: helmke h. J Agric Food Chem. 2023 Nov 29;71(47):18141-18168. doi: 10.1021/acs.jafc.3c01809. Epub 2023 Jun 5. J Agric Food Chem. 2023. PMID: 37277148 Review.
Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace.
Frackenpohl J, Schneider L, Decker LJB, Dittgen J, Fenkl F, Fischer C, Franke J, Freigang J, Getachew R, Gonzalez Fernandez-Nino SM, Helmke H, Hills MJ, Hohmann S, Kleemann J, Kurowski K, Lange G, Luemmen P, Meyering N, Poree F, Schmutzler D, Wrede S. Frackenpohl J, et al. Among authors: helmke h. Bioorg Med Chem. 2019 Dec 15;27(24):115142. doi: 10.1016/j.bmc.2019.115142. Epub 2019 Oct 19. Bioorg Med Chem. 2019. PMID: 31685332
Tetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins.
Frackenpohl J, Decker LJB, Dittgen J, Freigang J, Génix P, Helmke H, Lange G, Luemmen P, Schmidt J, Schmutzler D, Vors JP. Frackenpohl J, et al. Among authors: helmke h. Bioorg Med Chem. 2020 Nov 15;28(22):115725. doi: 10.1016/j.bmc.2020.115725. Epub 2020 Aug 30. Bioorg Med Chem. 2020. PMID: 33007548
Abscisic acid agonists suitable for optimizing plant water use.
Roeder J, Liu J, Doch I, Ruschhaupt M, Christmann A, Grill E, Helmke H, Hohmann S, Lehr S, Frackenpohl J, Yang Z. Roeder J, et al. Among authors: helmke h. Front Plant Sci. 2023 Jan 19;13:1071710. doi: 10.3389/fpls.2022.1071710. eCollection 2022. Front Plant Sci. 2023. PMID: 36743550 Free PMC article.
Design, synthesis and screening of herbicidal activity for new phenyl pyrazole-based protoporphyrinogen oxidase-inhibitors (PPO) overcoming resistance issues.
Mattison RL, Beffa R, Bojack G, Bollenbach-Wahl B, Dörnbrack C, Dorn N, Freigang J, Gatzweiler E, Getachew R, Hartfiel C, Heinemann I, Helmke H, Hohmann S, Jakobi H, Lange G, Lümmen P, Willms L, Frackenpohl J. Mattison RL, et al. Among authors: helmke h. Pest Manag Sci. 2023 Jun;79(6):2264-2280. doi: 10.1002/ps.7425. Epub 2023 Mar 8. Pest Manag Sci. 2023. PMID: 36815643
Designing New Protoporphyrinogen Oxidase-Inhibitors Carrying Potential Side Chain Isosteres to Enhance Crop Safety and Spectrum of Activity.
Alnafta N, Beffa R, Bojack G, Bollenbach-Wahl B, Brant NZ, Dörnbrack C, Dorn N, Freigang J, Gatzweiler E, Getachew R, Hartfiel C, Heinemann I, Helmke H, Hohmann S, Jakobi H, Lange G, Lümmen P, Willms L, Frackenpohl J. Alnafta N, et al. Among authors: helmke h. J Agric Food Chem. 2023 Nov 29;71(47):18270-18284. doi: 10.1021/acs.jafc.3c01420. Epub 2023 Jun 3. J Agric Food Chem. 2023. PMID: 37269295
A Study in Scaffold Hopping: Discovery and Optimization of Thiazolopyridines as Potent Herbicides That Inhibit Acyl-ACP Thioesterase.
Abel SAG, Alnafta N, Asmus E, Bollenbach-Wahl B, Braun R, Dittgen J, Endler A, Frackenpohl J, Freigang J, Gatzweiler E, Heinemann I, Helmke H, Laber B, Lange G, Machettira A, McArthur G, Müller T, Odaybat M, Reingruber AM, Roth S, Rosinger CH, Schmutzler D, Schulte W, Stoppel R, Tiebes J, Volpin G, Barber DM. Abel SAG, et al. Among authors: helmke h. J Agric Food Chem. 2023 Nov 29;71(47):18212-18226. doi: 10.1021/acs.jafc.3c02490. Epub 2023 Sep 7. J Agric Food Chem. 2023. PMID: 37677080