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Challenges in the development of heteromer-GPCR-based drugs.
Franco R, Martínez-Pinilla E, Ricobaraza A, McCormick PJ. Franco R, et al. Prog Mol Biol Transl Sci. 2013;117:143-62. doi: 10.1016/B978-0-12-386931-9.00006-4. Prog Mol Biol Transl Sci. 2013. PMID: 23663968 Review.
L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus.
Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE, Martínez-Pinilla E, Cortés A, Mallol J, Armentero MT, Pinna A, Canela EI, Lluís C, McCormick PJ, Lanciego JL, Casadó V, Franco R. Bonaventura J, et al. Neuropharmacology. 2014 Apr;79:90-100. doi: 10.1016/j.neuropharm.2013.10.036. Epub 2013 Nov 11. Neuropharmacology. 2014. PMID: 24230991
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.
Pinna A, Bonaventura J, Farré D, Sánchez M, Simola N, Mallol J, Lluís C, Costa G, Baqi Y, Müller CE, Cortés A, McCormick P, Canela EI, Martínez-Pinilla E, Lanciego JL, Casadó V, Armentero MT, Franco R. Pinna A, et al. Exp Neurol. 2014 Mar;253:180-91. doi: 10.1016/j.expneurol.2013.12.021. Epub 2014 Jan 9. Exp Neurol. 2014. PMID: 24412491
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Moreno B, Lopez I, Fernández-Díez B, Gottlieb M, Matute C, Sánchez-Gómez MV, Domercq M, Giralt A, Alberch J, Collon KW, Zhang H, Parent JM, Teixido M, Giralt E, Ceña V, Posadas I, Martínez-Pinilla E, Villoslada P, Franco R. Moreno B, et al. PLoS One. 2014 Mar 5;9(3):e90671. doi: 10.1371/journal.pone.0090671. eCollection 2014. PLoS One. 2014. PMID: 24599318 Free PMC article.
53 results