Sharma P - Search Results

1

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model.

Ranoa DRE, Sharma P, Schane CP, Lewis AN, Valdez E, Marada VVVR, Hager MV, Montgomery W, Wolf SP, Schreiber K, Schreiber H, Bailey K, Fan TM, Hergenrother PJ, Roy EJ, Kranz DM. Ranoa DRE, et al. Among authors: sharma p. J Immunother Cancer. 2023 May;11(5):e006509. doi: 10.1136/jitc-2022-006509. J Immunother Cancer. 2023. PMID: 37258040 Free PMC article.

2

Recent advances in T-cell engineering for use in immunotherapy.

Sharma P, Kranz DM. Sharma P, et al. F1000Res. 2016 Sep 19;5:F1000 Faculty Rev-2344. doi: 10.12688/f1000research.9073.1. eCollection 2016. F1000Res. 2016. PMID: 27703664 Free PMC article. Review.

3

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity.

Sharma P, Kranz DM. Sharma P, et al. J Biol Chem. 2018 Feb 2;293(5):1820-1834. doi: 10.1074/jbc.M117.814152. Epub 2017 Dec 11. J Biol Chem. 2018. PMID: 29229779 Free PMC article.

4

T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity.

Sharma P, Harris DT, Stone JD, Kranz DM. Sharma P, et al. Cancer Immunol Res. 2019 Dec;7(12):2025-2035. doi: 10.1158/2326-6066.CIR-19-0035. Epub 2019 Sep 23. Cancer Immunol Res. 2019. PMID: 31548259 Free PMC article.

5

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.

He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H. He Y, et al. Among authors: sharma p. JCI Insight. 2019 Nov 1;4(21):e130416. doi: 10.1172/jci.insight.130416. JCI Insight. 2019. PMID: 31672936 Free PMC article.

6

T Cell Receptors for Gene Transfer in Adoptive T Cell Therapy.

Sharma P, Kranz DM. Sharma P, et al. Crit Rev Immunol. 2019;39(2):105-122. doi: 10.1615/CritRevImmunol.2019030788. Crit Rev Immunol. 2019. PMID: 31679251 Review.

7

Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides.

Sharma P, Marada VVVR, Cai Q, Kizerwetter M, He Y, Wolf SP, Schreiber K, Clausen H, Schreiber H, Kranz DM. Sharma P, et al. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15148-15159. doi: 10.1073/pnas.1920662117. Epub 2020 Jun 15. Proc Natl Acad Sci U S A. 2020. PMID: 32541028 Free PMC article.

8

Soluble T cell receptor Vβ domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens.

Sharma P, Wang N, Kranz DM. Sharma P, et al. Toxins (Basel). 2014 Jan 28;6(2):556-74. doi: 10.3390/toxins6020556. Toxins (Basel). 2014. PMID: 24476714 Free PMC article. Review.

9

Engineering Proteins by Combining Deep Mutational Scanning and Yeast Display.

Sharma P, Procko E, Kranz DM. Sharma P, et al. Methods Mol Biol. 2022;2491:117-142. doi: 10.1007/978-1-0716-2285-8_7. Methods Mol Biol. 2022. PMID: 35482188

10

Characterization of the Staphylococcal enterotoxin A: Vβ receptor interaction using human receptor fragments engineered for high affinity.

Sharma P, Postel S, Sundberg EJ, Kranz DM. Sharma P, et al. Protein Eng Des Sel. 2013 Dec;26(12):781-9. doi: 10.1093/protein/gzt054. Epub 2013 Oct 27. Protein Eng Des Sel. 2013. PMID: 24167300 Free PMC article.

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