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The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance.
Sanese P, De Marco K, Lepore Signorile M, La Rocca F, Forte G, Latrofa M, Fasano C, Disciglio V, Di Nicola E, Pantaleo A, Bianco G, Spilotro V, Ferroni C, Tubertini M, Labarile N, De Marinis L, Armentano R, Gigante G, Lantone V, Lantone G, Naldi M, Bartolini M, Varchi G, Del Rio A, Grossi V, Simone C. Sanese P, et al. Among authors: varchi g. J Exp Clin Cancer Res. 2024 May 30;43(1):151. doi: 10.1186/s13046-024-03078-9. J Exp Clin Cancer Res. 2024. PMID: 38812026 Free PMC article.
SMYD3 Modulates AMPK-mTOR Signaling Balance in Cancer Cell Response to DNA Damage.
Lepore Signorile M, Sanese P, Di Nicola E, Fasano C, Forte G, De Marco K, Disciglio V, Latrofa M, Pantaleo A, Varchi G, Del Rio A, Grossi V, Simone C. Lepore Signorile M, et al. Among authors: varchi g. Cells. 2023 Nov 17;12(22):2644. doi: 10.3390/cells12222644. Cells. 2023. PMID: 37998381 Free PMC article.
SMYD3 Modulates the HGF/MET Signaling Pathway in Gastric Cancer.
De Marco K, Lepore Signorile M, Di Nicola E, Sanese P, Fasano C, Forte G, Disciglio V, Pantaleo A, Varchi G, Del Rio A, Grossi V, Simone C. De Marco K, et al. Among authors: varchi g. Cells. 2023 Oct 18;12(20):2481. doi: 10.3390/cells12202481. Cells. 2023. PMID: 37887325 Free PMC article.
Drug Delivery in Photodynamic Therapy.
Moret F, Varchi G. Moret F, et al. Among authors: varchi g. Pharmaceutics. 2023 Jun 21;15(7):1784. doi: 10.3390/pharmaceutics15071784. Pharmaceutics. 2023. PMID: 37513971 Free PMC article.
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3.
Parenti MD, Naldi M, Manoni E, Fabini E, Cederfelt D, Talibov VO, Gressani V, Guven U, Grossi V, Fasano C, Sanese P, De Marco K, Shtil AA, Kurkin AV, Altieri A, Danielson UH, Caretti G, Simone C, Varchi G, Bartolini M, Del Rio A. Parenti MD, et al. Among authors: varchi g. Eur J Med Chem. 2022 Dec 5;243:114683. doi: 10.1016/j.ejmech.2022.114683. Epub 2022 Sep 8. Eur J Med Chem. 2022. PMID: 36116234
Correction to "Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents".
Fallica AN, Barbaraci C, Amata E, Pasquinucci L, Turnaturi R, Dichiara M, Intagliata S, Gariboldi MB, Marras E, Orlandi VT, Ferroni C, Martini C, Rescifina A, Gentile D, Varchi G, Marrazzo A. Fallica AN, et al. Among authors: varchi g. J Med Chem. 2022 Aug 25;65(16):11414. doi: 10.1021/acs.jmedchem.2c01209. Epub 2022 Aug 10. J Med Chem. 2022. PMID: 35947791 Free PMC article. No abstract available.
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