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What was old is new again: Phenotypic screening of a unique fungal library yields pyridoxatin, a promising lead against extensively resistant Acinetobacter baumannii (AB5075).
Winter HL, Flores-Bocanegra L, Cank KB, Crandall WJ, Rotich FC, Tillman MN, Todd DA, Graf TN, Raja HA, Pearce CJ, Oberlies NH, Cech NB. Winter HL, et al. Phytochem Lett. 2023 Jun;55:88-96. doi: 10.1016/j.phytol.2023.04.002. Epub 2023 Apr 21. Phytochem Lett. 2023. PMID: 37252254 Free PMC article.
Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis.
Williams MR, Costa SK, Zaramela LS, Khalil S, Todd DA, Winter HL, Sanford JA, O'Neill AM, Liggins MC, Nakatsuji T, Cech NB, Cheung AL, Zengler K, Horswill AR, Gallo RL. Williams MR, et al. Among authors: winter hl. Sci Transl Med. 2019 May 1;11(490):eaat8329. doi: 10.1126/scitranslmed.aat8329. Sci Transl Med. 2019. PMID: 31043573 Free PMC article.
2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. Baxter EW, et al. Among authors: winter hl. J Med Chem. 2007 Sep 6;50(18):4261-4. doi: 10.1021/jm0705408. Epub 2007 Aug 8. J Med Chem. 2007. PMID: 17685503
A painful swelling on the chest. Thoracic actinomycosis.
Huits RM, Winter HL, Slebos DJ. Huits RM, et al. Among authors: winter hl. Clin Infect Dis. 2006 Jan 1;42(1):100-2, 148-50. doi: 10.1086/498513. Clin Infect Dis. 2006. PMID: 16329211 No abstract available.
21 results