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A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Allen SP, Al Sultan A, Kabucho Kibirige E, Tonkiss E, Hamer KJ, Castelli LM, Lin YH, Roscoe S, Stefanidis N, Mead RJ, Highley JR, Cooper-Knock J, Hautbergue GM, Heath PR, Kirby J, Shaw PJ. Allen SP, et al. Among authors: heath pr. Front Aging Neurosci. 2023 May 11;15:1151848. doi: 10.3389/fnagi.2023.1151848. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37251807 Free PMC article.
Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.
Allen S, Heath PR, Kirby J, Wharton SB, Cookson MR, Menzies FM, Banks RE, Shaw PJ. Allen S, et al. Among authors: heath pr. J Biol Chem. 2003 Feb 21;278(8):6371-83. doi: 10.1074/jbc.M209915200. Epub 2002 Dec 9. J Biol Chem. 2003. PMID: 12475980 Free article.
Gene expression assays.
Kirby J, Heath PR, Shaw PJ, Hamdy FC. Kirby J, et al. Among authors: heath pr. Adv Clin Chem. 2007;44:247-92. doi: 10.1016/s0065-2423(07)44008-2. Adv Clin Chem. 2007. PMID: 17682345 Review.
123 results