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Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides.
Adams R, Joyce C, Kuravskiy M, Harrison K, Ahdash Z, Balmforth M, Chia K, Marceddu C, Coates M, Snowden J, Goursaud E, Ménochet K, van den Elsen J, Payne RJ, Lawson ADG, Scott-Tucker A, Macpherson A. Adams R, et al. Among authors: van den elsen j. Front Immunol. 2023 May 12;14:1170357. doi: 10.3389/fimmu.2023.1170357. eCollection 2023. Front Immunol. 2023. PMID: 37251411 Free PMC article.
Insights Into the Structure-Function Relationships of Dimeric C3d Fragments.
Wahid AA, Dunphy RW, Macpherson A, Gibson BG, Kulik L, Whale K, Back C, Hallam TM, Alkhawaja B, Martin RL, Meschede I, Laabei M, Lawson ADG, Holers VM, Watts AG, Crennell SJ, Harris CL, Marchbank KJ, van den Elsen JMH. Wahid AA, et al. Among authors: van den elsen jmh. Front Immunol. 2021 Aug 9;12:714055. doi: 10.3389/fimmu.2021.714055. eCollection 2021. Front Immunol. 2021. PMID: 34434196 Free PMC article.
The Chemical Synthesis of Knob Domain Antibody Fragments.
Macpherson A, Birtley JR, Broadbridge RJ, Brady K, Schulze MED, Tang Y, Joyce C, Saunders K, Bogle G, Horton J, Kelm S, Taylor RD, Franklin RJ, Selby MD, Laabei M, Wonfor T, Hold A, Stanley P, Vadysirisack D, Shi J, van den Elsen J, Lawson ADG. Macpherson A, et al. Among authors: van den elsen j. ACS Chem Biol. 2021 Sep 17;16(9):1757-1769. doi: 10.1021/acschembio.1c00472. Epub 2021 Aug 18. ACS Chem Biol. 2021. PMID: 34406751 Free article.
A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity.
Nilsson PH, Johnson C, Quach QH, Macpherson A, Durrant O, Pischke SE, Fure H, Landsem A, Bergseth G, Schjalm C, Haugaard-Kedström LM, Huber-Lang M, van den Elsen J, Brekke OL, Mollnes TE. Nilsson PH, et al. Among authors: van den elsen j. J Immunol. 2021 Sep 15;207(6):1641-1651. doi: 10.4049/jimmunol.2001471. Epub 2021 Aug 11. J Immunol. 2021. PMID: 34380648 Free PMC article.
The allosteric modulation of complement C5 by knob domain peptides.
Macpherson A, Laabei M, Ahdash Z, Graewert MA, Birtley JR, Schulze ME, Crennell S, Robinson SA, Holmes B, Oleinikovas V, Nilsson PH, Snowden J, Ellis V, Mollnes TE, Deane CM, Svergun D, Lawson AD, van den Elsen JM. Macpherson A, et al. Among authors: van den elsen jm. Elife. 2021 Feb 11;10:e63586. doi: 10.7554/eLife.63586. Elife. 2021. PMID: 33570492 Free PMC article.
Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies.
Macpherson A, Scott-Tucker A, Spiliotopoulos A, Simpson C, Staniforth J, Hold A, Snowden J, Manning L, van den Elsen J, Lawson ADG. Macpherson A, et al. Among authors: van den elsen j. PLoS Biol. 2020 Sep 4;18(9):e3000821. doi: 10.1371/journal.pbio.3000821. eCollection 2020 Sep. PLoS Biol. 2020. PMID: 32886672 Free PMC article.
Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift.
Knight MJ, Woolley RE, Kwok A, Parsons S, Jones HBL, Gulácsy CE, Phaal P, Kassaar O, Dawkins K, Rodriguez E, Marques A, Bowsher L, Wells SA, Watts A, van den Elsen JMH, Turner A, O'Hara J, Pudney CR. Knight MJ, et al. Among authors: van den elsen jmh. Biochem J. 2020 Sep 30;477(18):3599-3612. doi: 10.1042/BCJ20200580. Biochem J. 2020. PMID: 32869839 Free PMC article.
58 results