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In Silico Discovery and Predictive Modeling of Novel Acetylcholinesterase (AChE) Inhibitors for Alzheimer's Treatment.
Suha HN, Hossain MS, Rahman S, Alodhayb A, Hossain MM, Kawsar SMA, Poirier R, Uddin KM. Suha HN, et al. Med Chem. 2024 May 27. doi: 10.2174/0115734064304100240511112619. Online ahead of print. Med Chem. 2024. PMID: 38803179
By scrutinizing their interactions with 11 essential target proteins (AChE, Abeta, BChE, GSK-3beta, MAO B, PDE-9, Prion, PSEN-1, sEH, Tau, and TDP-43) and comparing them with established drugs such as donepezil, galantamine, memantine, and rivastigmine, ligand 14 em …
By scrutinizing their interactions with 11 essential target proteins (AChE, Abeta, BChE, GSK-3beta, MAO B, PDE-9, Prion, PSEN- …
Identification and optimization of nitrophenolic analogues as dopamine metabolic enzyme inhibitors for the treatment of Parkinson's disease.
Zou M, Wu Y, Lan Y, Xie H, Sun H, Liu W, Feng F, Jiang X. Zou M, et al. Bioorg Chem. 2024 May 23;148:107488. doi: 10.1016/j.bioorg.2024.107488. Online ahead of print. Bioorg Chem. 2024. PMID: 38797066
Simultaneous inhibition of the two key dopamine metabolic enzymes, catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAO-B), could potentially be a breakthrough in achieving clinical efficacy. ...
Simultaneous inhibition of the two key dopamine metabolic enzymes, catechol-O-methyltransferase (COMT) and monoamine oxidase B …
In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model.
Kumar N, Jangid K, Kumar V, Yadav RP, Mishra J, Upadhayay S, Kumar V, Devi B, Kumar V, Dwivedi AR, Kumar P, Baranwal S, Bhatti JS, Kumar V. Kumar N, et al. ACS Chem Neurosci. 2024 May 25. doi: 10.1021/acschemneuro.4c00007. Online ahead of print. ACS Chem Neurosci. 2024. PMID: 38795037
The synthesized compounds exhibited multipotent activity against AChE, BuChE, MAO-B, and amyloid beta aggregation. Three potent compounds, i.e., VN-3, VN-14, and VN-19 were identified that displayed remarkable activities against different targets. ...Compound VN-19 …
The synthesized compounds exhibited multipotent activity against AChE, BuChE, MAO-B, and amyloid beta aggregation. Three poten …
Development of scoring-assisted generative exploration (SAGE) and its application to dual inhibitor design for acetylcholinesterase and monoamine oxidase B.
Lim H. Lim H. J Cheminform. 2024 May 24;16(1):59. doi: 10.1186/s13321-024-00845-w. J Cheminform. 2024. PMID: 38790018 Free PMC article.
Furthermore, I suggested a top-ranked molecule with SAGE as dual inhibitors of acetylcholinesterase and monoamine oxidase B through multiple desired property optimization. ...Additionally, the application of SAGE to discover dual inhibitors for acetylcholinesterase …
Furthermore, I suggested a top-ranked molecule with SAGE as dual inhibitors of acetylcholinesterase and monoamine oxidase B th …
Safinamide as adjunctive therapy to levodopa monotherapy for patients with Parkinson's disease with wearing-off: The Japanese observational J-SILVER study.
Nishikawa N, Hatano T, Nishioka K, Ueno SI, Saiki S, Nakamura R, Yoritaka A, Ogawa T, Shimo Y, Sako W, Shimura H, Furukawa Y, Kamei T, Ishida T, Hattori N; J-SILVER study group. Nishikawa N, et al. J Neurol Sci. 2024 May 17;461:123051. doi: 10.1016/j.jns.2024.123051. Online ahead of print. J Neurol Sci. 2024. PMID: 38788287 Free article.
Role of Vasoactive Hormone-Induced Signal Transduction in Cardiac Hypertrophy and Heart Failure.
Dhalla NS, Mota KO, Elimban V, Shah AK, de Vasconcelos CML, Bhullar SK. Dhalla NS, et al. Cells. 2024 May 17;13(10):856. doi: 10.3390/cells13100856. Cells. 2024. PMID: 38786079 Free PMC article. Review.
The prolonged exposure of the hypertrophied heart to these vasoactive hormones has been reported to result in the oxidation of catecholamines and serotonin via monoamine oxidase as well as the activation of NADPH oxidase via angiotensin II and endothelins to …
The prolonged exposure of the hypertrophied heart to these vasoactive hormones has been reported to result in the oxidation of catecholamine …
27,006 results
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