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Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1.
Silva Dos Santos D, Turaça LT, Coutinho KCDS, Barbosa RAQ, Polidoro JZ, Kasai-Brunswick TH, Campos de Carvalho AC, Girardi ACC. Silva Dos Santos D, et al. Among authors: polidoro jz. Sci Rep. 2023 May 29;13(1):8689. doi: 10.1038/s41598-023-35944-5. Sci Rep. 2023. PMID: 37248416 Free PMC article.
Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure.
Borges-Júnior FA, Silva Dos Santos D, Benetti A, Polidoro JZ, Wisnivesky ACT, Crajoinas RO, Antônio EL, Jensen L, Caramelli B, Malnic G, Tucci PJ, Girardi ACC. Borges-Júnior FA, et al. Among authors: polidoro jz. J Am Soc Nephrol. 2021 Jul;32(7):1616-1629. doi: 10.1681/ASN.2020071029. Epub 2021 Apr 12. J Am Soc Nephrol. 2021. PMID: 33846238 Free PMC article.
Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling.
Carneiro de Morais CP, Polidoro JZ, Ralph DL, Pessoa TD, Oliveira-Souza M, Barauna VG, Rebouças NA, Malnic G, McDonough AA, Girardi AC. Carneiro de Morais CP, et al. Among authors: polidoro jz. Am J Physiol Cell Physiol. 2015 Oct 15;309(8):C541-50. doi: 10.1152/ajpcell.00072.2015. Epub 2015 Aug 5. Am J Physiol Cell Physiol. 2015. PMID: 26246427 Free PMC article.
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