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A Novel bispecific T-cell engager (BiTE) targeting CD22 and CD3 has both in vitro and in vivo activity and synergizes with blinatumomab in an acute lymphoblastic leukemia (ALL) tumor model.
Cancer Immunol Immunother. 2023 Sep;72(9):2939-2948. doi: 10.1007/s00262-023-03444-0. Epub 2023 May 29.
Cancer Immunol Immunother. 2023.
PMID: 37247022
Free PMC article.
KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth.
Shimoda M, Lyu Y, Wang KH, Kumar A, Miura H, Meckler JF, Davis RR, Chantarasrivong C, Izumiya C, Tepper CG, Nakajima KI, Tuscano J, Barisone G, Izumiya Y.
Shimoda M, et al. Among authors: meckler jf.
Commun Biol. 2021 Dec 2;4(1):1330. doi: 10.1038/s42003-021-02853-0.
Commun Biol. 2021.
PMID: 34857874
Free PMC article.
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A Fermented Wheat Germ Extract Contains Protein Components Active against NSCLC Xenografts In Vivo.
Levis DJ, Meckler JF, O'Donnell RT, Tuscano JM.
Levis DJ, et al. Among authors: meckler jf.
Curr Issues Mol Biol. 2023 Aug 25;45(9):7087-7096. doi: 10.3390/cimb45090448.
Curr Issues Mol Biol. 2023.
PMID: 37754232
Free PMC article.
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Quantitative analysis of TALE-DNA interactions suggests polarity effects.
Meckler JF, Bhakta MS, Kim MS, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal DJ, Baldwin EP.
Meckler JF, et al.
Nucleic Acids Res. 2013 Apr;41(7):4118-28. doi: 10.1093/nar/gkt085. Epub 2013 Feb 13.
Nucleic Acids Res. 2013.
PMID: 23408851
Free PMC article.
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Highly active zinc-finger nucleases by extended modular assembly.
Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ.
Bhakta MS, et al. Among authors: meckler jf.
Genome Res. 2013 Mar;23(3):530-8. doi: 10.1101/gr.143693.112. Epub 2012 Dec 5.
Genome Res. 2013.
PMID: 23222846
Free PMC article.
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A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture.
O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal DJ.
O'Geen H, et al. Among authors: meckler jf.
Nucleic Acids Res. 2015 Mar 31;43(6):3389-404. doi: 10.1093/nar/gkv137. Epub 2015 Feb 20.
Nucleic Acids Res. 2015.
PMID: 25712100
Free PMC article.
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Genome engineering at the dawn of the golden age.
Segal DJ, Meckler JF.
Segal DJ, et al. Among authors: meckler jf.
Annu Rev Genomics Hum Genet. 2013;14:135-58. doi: 10.1146/annurev-genom-091212-153435. Epub 2013 May 20.
Annu Rev Genomics Hum Genet. 2013.
PMID: 23701416
Review.
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Adding fingers to an engineered zinc finger nuclease can reduce activity.
Shimizu Y, Şöllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ.
Shimizu Y, et al. Among authors: meckler jf.
Biochemistry. 2011 Jun 7;50(22):5033-41. doi: 10.1021/bi200393g. Epub 2011 May 11.
Biochemistry. 2011.
PMID: 21528840
Free PMC article.
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