Xu Y - Search Results

1

Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C disease.

Chen J, Soni RK, Xu Y, Simoes S, Liang FX, DeFreitas L, Hwang R Jr, Montesinos J, Lee JH, Area-Gomez E, Nandakumar R, Vardarajan B, Marquer C. Chen J, et al. Among authors: xu y. EBioMedicine. 2023 Jun;92:104628. doi: 10.1016/j.ebiom.2023.104628. Epub 2023 May 26. EBioMedicine. 2023. PMID: 37245481 Free PMC article.

2

Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate.

Chen J, Cazenave-Gassiot A, Xu Y, Piroli P, Hwang R Jr, DeFreitas L, Chan RB, Di Paolo G, Nandakumar R, Wenk MR, Marquer C. Chen J, et al. Among authors: xu y. Commun Biol. 2023 Feb 23;6(1):210. doi: 10.1038/s42003-023-04573-z. Commun Biol. 2023. PMID: 36823305 Free PMC article.

3

The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking.

Montesinos J, Pera M, Larrea D, Guardia-Laguarta C, Agrawal RR, Velasco KR, Yun TD, Stavrovskaya IG, Xu Y, Koo SY, Snead AM, Sproul AA, Area-Gomez E. Montesinos J, et al. Among authors: xu y. EMBO J. 2020 Oct 15;39(20):e103791. doi: 10.15252/embj.2019103791. Epub 2020 Aug 31. EMBO J. 2020. PMID: 32865299 Free PMC article.

4

Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice.

Miranda AM, Ashok A, Chan RB, Zhou B, Xu Y, McIntire LB, Area-Gomez E, Di Paolo G, Duff KE, Oliveira TG, Nuriel T. Miranda AM, et al. Among authors: xu y. Transl Psychiatry. 2022 Mar 29;12(1):129. doi: 10.1038/s41398-022-01881-6. Transl Psychiatry. 2022. PMID: 35351864 Free PMC article.

5

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.

Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G. Miranda AM, et al. Among authors: xu y. Nat Commun. 2018 Jan 18;9(1):291. doi: 10.1038/s41467-017-02533-w. Nat Commun. 2018. PMID: 29348617 Free PMC article.

6

Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders.

Area-Gomez E, Larrea D, Yun T, Xu Y, Hupf J, Zandkarimi F, Chan RB, Mitsumoto H. Area-Gomez E, et al. Among authors: xu y. Sci Rep. 2021 Jun 30;11(1):13562. doi: 10.1038/s41598-021-92112-3. Sci Rep. 2021. PMID: 34193885 Free PMC article. Clinical Trial.

7

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.

Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, Xu Y, Chan RB, Di Paolo G, Mehler MF, Perumal GS, Macaluso FP, Freyberg ZZ, Acin-Perez R, Enriquez JA, Schon EA, Area-Gomez E. Pera M, et al. Among authors: xu y. EMBO J. 2017 Nov 15;36(22):3356-3371. doi: 10.15252/embj.201796797. Epub 2017 Oct 10. EMBO J. 2017. PMID: 29018038 Free PMC article.

8

CoQ₁₀ supplementation rescues nephrotic syndrome through normalization of H₂S oxidation pathway.

Kleiner G, Barca E, Ziosi M, Emmanuele V, Xu Y, Hidalgo-Gutierrez A, Qiao C, Tadesse S, Area-Gomez E, Lopez LC, Quinzii CM. Kleiner G, et al. Among authors: xu y. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3708-3722. doi: 10.1016/j.bbadis.2018.09.002. Epub 2018 Sep 6. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 30251690 Free PMC article.

9

Alzheimer's-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury.

Agrawal RR, Larrea D, Xu Y, Shi L, Zirpoli H, Cummins LG, Emmanuele V, Song D, Yun TD, Macaluso FP, Min W, Kernie SG, Deckelbaum RJ, Area-Gomez E. Agrawal RR, et al. Among authors: xu y. Cell Mol Neurobiol. 2023 Jul;43(5):2219-2241. doi: 10.1007/s10571-022-01299-0. Epub 2022 Dec 26. Cell Mol Neurobiol. 2023. PMID: 36571634 Free PMC article.

10

Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD).

Agudelo CW, Kumley BK, Area-Gomez E, Xu Y, Dabo AJ, Geraghty P, Campos M, Foronjy R, Garcia-Arcos I. Agudelo CW, et al. Among authors: xu y. PLoS One. 2020 Feb 6;15(2):e0228279. doi: 10.1371/journal.pone.0228279. eCollection 2020. PLoS One. 2020. PMID: 32027677 Free PMC article.

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