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Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
Linghu KG, Zhang T, Zhang GT, Lv P, Zhang WJ, Zhao GD, Xiong SH, Ma QS, Zhao MM, Chen M, Hu YJ, Zhang CS, Yu H. Linghu KG, et al. Among authors: zhang t, zhang gt, zhang wj, zhang cs. J Pharm Anal. 2024 Mar;14(3):401-415. doi: 10.1016/j.jpha.2023.07.009. Epub 2023 Jul 17. J Pharm Anal. 2024. PMID: 38618249 Free PMC article.
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