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Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.
Nat Cancer. 2023 May;4(5):754-773. doi: 10.1038/s43018-023-00550-x. Epub 2023 May 26.
Nat Cancer. 2023.
PMID: 37237081
Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.
Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Brüggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, Hengeveld PJ, Glassner BJ, Dhimolea E, Ott CJ, Zhang T, Kwiatkowski NP, Laubach JP, Schlossman RL, Richardson PG, Culhane AC, Groen RWJ, Fischer ES, Vazquez F, Tsherniak A, Hahn WC, Levy J, Auclair D, Licht JD, Keats JJ, Boise LH, Ebert BL, Bradner JE, Gray NS, Mitsiades CS.
Shirasaki R, et al. Among authors: downey kopyscinski sl.
Cell Rep. 2021 Jan 5;34(1):108532. doi: 10.1016/j.celrep.2020.108532.
Cell Rep. 2021.
PMID: 33406420
Free PMC article.
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M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models.
Sanderson MP, Friese-Hamim M, Walter-Bausch G, Busch M, Gaus S, Musil D, Rohdich F, Zanelli U, Downey-Kopyscinski SL, Mitsiades CS, Schadt O, Klein M, Esdar C.
Sanderson MP, et al. Among authors: downey kopyscinski sl.
Mol Cancer Ther. 2021 Aug;20(8):1378-1387. doi: 10.1158/1535-7163.MCT-21-0005. Epub 2021 May 27.
Mol Cancer Ther. 2021.
PMID: 34045234
Free PMC article.
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An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors.
Downey-Kopyscinski S, Daily EW, Gautier M, Bhatt A, Florea BI, Mitsiades CS, Richardson PG, Driessen C, Overkleeft HS, Kisselev AF.
Downey-Kopyscinski S, et al.
Blood Adv. 2018 Oct 9;2(19):2443-2451. doi: 10.1182/bloodadvances.2018016360.
Blood Adv. 2018.
PMID: 30266819
Free PMC article.
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Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL-AF4 fusion protein.
Jenkins TW, Downey-Kopyscinski SL, Fields JL, Rahme GJ, Colley WC, Israel MA, Maksimenko AV, Fiering SN, Kisselev AF.
Jenkins TW, et al. Among authors: downey kopyscinski sl.
Sci Rep. 2021 May 25;11(1):10883. doi: 10.1038/s41598-021-90451-9.
Sci Rep. 2021.
PMID: 34035431
Free PMC article.
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A clinically relevant pulse treatment generates a bortezomib-resistant myeloma cell line that lacks proteasome mutations and is sensitive to Bcl-2 inhibitor venetoclax.
Downey-Kopyscinski SL, Srinivasa S, Kisselev AF.
Downey-Kopyscinski SL, et al.
Sci Rep. 2022 Jul 27;12(1):12788. doi: 10.1038/s41598-022-17239-3.
Sci Rep. 2022.
PMID: 35896610
Free PMC article.
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