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Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion.
Murahashi Y, Yano F, Chijimatsu R, Nakamoto H, Maenohara Y, Amakawa M, Miyake Y, Yamanaka H, Iba K, Yamashita T, Tanaka S, Saito T. Murahashi Y, et al. Among authors: amakawa m. Sci Rep. 2019 Dec 30;9(1):20329. doi: 10.1038/s41598-019-56861-6. Sci Rep. 2019. PMID: 31889132 Free PMC article.
KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration.
Watanabe Y, Murata T, Amakawa M, Miyake Y, Handa T, Konishi K, Matsumura Y, Tanaka T, Takeuchi K. Watanabe Y, et al. Among authors: amakawa m. Eur J Pharmacol. 2015 May 5;754:179-89. doi: 10.1016/j.ejphar.2015.02.021. Epub 2015 Feb 19. Eur J Pharmacol. 2015. PMID: 25704618 Free article.
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