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The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential.
Curr Issues Mol Biol. 2023 May 11;45(5):4228-4245. doi: 10.3390/cimb45050269.
Curr Issues Mol Biol. 2023.
PMID: 37232738
Free PMC article.
Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells.
Quintela M, James DW, Pociute A, Powell L, Edwards K, Coombes Z, Garcia J, Garton N, Das N, Lutchman-Singh K, Margarit L, Beynon AL, Rioja I, Prinjha RK, Harker NR, Gonzalez D, Conlan RS, Francis LW.
Quintela M, et al. Among authors: harker nr.
Clin Epigenetics. 2023 Apr 15;15(1):63. doi: 10.1186/s13148-023-01477-x.
Clin Epigenetics. 2023.
PMID: 37060086
Free PMC article.
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In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer.
Quintela M, James DW, Garcia J, Edwards K, Margarit L, Das N, Lutchman-Singh K, Beynon AL, Rioja I, Prinjha RK, Harker NR, Gonzalez D, Steven Conlan R, Francis LW.
Quintela M, et al. Among authors: harker nr.
Br J Cancer. 2023 Jul;129(1):163-174. doi: 10.1038/s41416-023-02274-2. Epub 2023 Apr 29.
Br J Cancer. 2023.
PMID: 37120667
Free PMC article.
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Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
Ghiboub M, Koster J, Craggs PD, Li Yim AYF, Shillings A, Hutchinson S, Bingham RP, Gatfield K, Hageman IL, Yao G, O'Keefe HP, Coffin A, Patel A, Sloan LA, Mitchell DJ, Hayhow TG, Lunven L, Watson RJ, Blunt CE, Harrison LA, Bruton G, Kumar U, Hamer N, Spaull JR, Zwijnenburg DA, Welting O, Hakvoort TBM, Te Velde AA, van Limbergen J, Henneman P, Prinjha RK, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ.
Ghiboub M, et al. Among authors: harker nr.
BMC Biol. 2022 Aug 19;20(1):182. doi: 10.1186/s12915-022-01380-6.
BMC Biol. 2022.
PMID: 35986286
Free PMC article.
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Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives.
Ghiboub M, Elfiky AMI, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ.
Ghiboub M, et al. Among authors: harker nr.
J Pers Med. 2021 Apr 23;11(5):336. doi: 10.3390/jpm11050336.
J Pers Med. 2021.
PMID: 33922725
Free PMC article.
Review.
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HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages.
Ghiboub M, Zhao J, Li Yim AYF, Schilderink R, Verseijden C, van Hamersveld PHP, Duarte JM, Hakvoort TBM, Admiraal I, Harker NR, Tough DF, Henneman P, de Winther MPJ, de Jonge WJ.
Ghiboub M, et al. Among authors: harker nr.
Front Immunol. 2020 Oct 5;11:550769. doi: 10.3389/fimmu.2020.550769. eCollection 2020.
Front Immunol. 2020.
PMID: 33123128
Free PMC article.
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Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation.
Gilan O, Rioja I, Knezevic K, Bell MJ, Yeung MM, Harker NR, Lam EYN, Chung CW, Bamborough P, Petretich M, Urh M, Atkinson SJ, Bassil AK, Roberts EJ, Vassiliadis D, Burr ML, Preston AGS, Wellaway C, Werner T, Gray JR, Michon AM, Gobbetti T, Kumar V, Soden PE, Haynes A, Vappiani J, Tough DF, Taylor S, Dawson SJ, Bantscheff M, Lindon M, Drewes G, Demont EH, Daniels DL, Grandi P, Prinjha RK, Dawson MA.
Gilan O, et al. Among authors: harker nr.
Science. 2020 Apr 24;368(6489):387-394. doi: 10.1126/science.aaz8455. Epub 2020 Mar 19.
Science. 2020.
PMID: 32193360
Free PMC article.
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Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762.
Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry MS, Rotolo A, Tough DF, Smithers NN, Bassil AK, Chapman TD, Harker NR, Barbash O, Tummino P, Al-Mahdi N, Haynes AC, Cutler L, Le B, Rahemtulla A, Roberts I, Kleijnen M, Witherington JJ, Parr NJ, Prinjha RK, Karadimitris A.
Chaidos A, et al. Among authors: harker nr.
Blood. 2014 Jan 30;123(5):697-705. doi: 10.1182/blood-2013-01-478420. Epub 2013 Dec 13.
Blood. 2014.
PMID: 24335499
Free article.
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