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Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2.
Verstraete MM, Heinkel F, Li J, Cao S, Tran A, Halverson EC, Gene R, Stangle E, Silva-Moreno B, Arrafi S, Bavananthasivam J, Fung M, Eji-Lasisi M, Masterman S, Xanthoudakis S, Dixit S, Babcook J, Clavette B, Fogg M, Escobar-Cabrera E. Verstraete MM, et al. Among authors: gene r. MAbs. 2023 Jan-Dec;15(1):2212415. doi: 10.1080/19420862.2023.2212415. MAbs. 2023. PMID: 37229608 Free PMC article.
Vpr driving DNA methylation variation of CD4 + T cells in HIV-1 infection.
Wang P, Meng Z, Deng K, Gao Z, Cai J. Wang P, et al. Virol J. 2024 Apr 26;21(1):97. doi: 10.1186/s12985-024-02363-5. Virol J. 2024. PMID: 38671522 Free PMC article.
These alterations notably influence genes related to immune-related pathways and olfactory receptor activity. Moreover, Vpr demonstrates a distinct ability to diminish the levels of methylation in histone genes. ...
These alterations notably influence genes related to immune-related pathways and olfactory receptor activity. Moreover, Vpr de …
Identification of microRNAs and their target genes associated with chasmogamous and cleistogamous flower development in Viola prionantha.
Li Q, Zhang Z, Li K, Zhu Y, Sun K, He C. Li Q, et al. Planta. 2024 Apr 9;259(5):116. doi: 10.1007/s00425-024-04398-y. Planta. 2024. PMID: 38592549
In the auxin-activated signaling pathway, vpr-miR393a/b and vpr-miRN2005 could target Vpr-TIR1/AFB and Vpr-ARF2, respectively, and other DEmiRNAs could target genes involved in the regulation of transcription, e.g., Vpr-AP2-7. ...Some V. …
In the auxin-activated signaling pathway, vpr-miR393a/b and vpr-miRN2005 could target Vpr-TIR1/AFB and Vpr-ARF2, …
HIV-1 Vpr Functions in Primary CD4(+) T Cells.
Vanegas-Torres CA, Schindler M. Vanegas-Torres CA, et al. Viruses. 2024 Mar 9;16(3):420. doi: 10.3390/v16030420. Viruses. 2024. PMID: 38543785 Free PMC article. Review.
HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes. Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to exert various biological effects on the host cell upon delivery. In this way, Vpr …
HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes. Uniquely amongst them, Vpr is abundan …
Exploring the potential of structural modeling and molecular docking for efficient siRNA screening: A promising approach to Combat viral mutants, with a focus on HIV-1.
Nematian M, Noormohammadi Z, Rahimi P, Irani S, Arefian E. Nematian M, et al. Biochem Biophys Res Commun. 2024 May 14;708:149769. doi: 10.1016/j.bbrc.2024.149769. Epub 2024 Mar 11. Biochem Biophys Res Commun. 2024. PMID: 38518723
RNA interference (RNAi) holds immense potential for sequence-specific downregulation of disease-related genes. Small interfering RNA (siRNA) therapy has made remarkable strides, with FDA approval for treating specific human diseases, showcasing its promising future in dise …
RNA interference (RNAi) holds immense potential for sequence-specific downregulation of disease-related genes. Small interfering RNA …
Multiplexed Transactivation of Mammalian Cells Using dFnCas12a-VPR.
Bryson JW, Rosser SJ. Bryson JW, et al. Methods Mol Biol. 2024;2774:193-204. doi: 10.1007/978-1-0716-3718-0_13. Methods Mol Biol. 2024. PMID: 38441766
With few exceptions, most diseases are caused by complex polygenic interactions, with multiple genes contributing to define the output of a gene network. As such researchers are increasingly interested in tools that can offer not only control but also the capacity to simul …
With few exceptions, most diseases are caused by complex polygenic interactions, with multiple genes contributing to define the outpu …
Transcriptomics of temperature-sensitive R gene-mediated resistance identifies a WAKL10 protein interaction network.
Noel K, Wolf IR, Hughes D, Valente GT, Qi A, Huang YJ, Fitt BDL, Stotz HU. Noel K, et al. Sci Rep. 2024 Feb 29;14(1):5023. doi: 10.1038/s41598-024-53643-7. Sci Rep. 2024. PMID: 38424101 Free PMC article.
Here, we show that resistance of Brassica napus cotyledons against Leptosphaeria maculans was temperature-sensitive in introgression line Topas-Rlm7 but temperature-resilient in Topas-Rlm4. A set of 1,646 host genes was differentially expressed in Topas-Rlm4 and Topas-Rlm7 …
Here, we show that resistance of Brassica napus cotyledons against Leptosphaeria maculans was temperature-sensitive in introgression line To …
689 results