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Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology.
J Am Chem Soc. 2024 Feb 28;146(8):5204-5214. doi: 10.1021/jacs.3c11153. Epub 2024 Feb 15.
J Am Chem Soc. 2024.
PMID: 38358897
Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans.
Mazurkewich S, Scholzen KC, Brusch RH, Poulsen JCN, Theibich Y, Hüttner S, Olsson L, Larsbrink J, Lo Leggio L.
Mazurkewich S, et al. Among authors: scholzen kc.
Acta Crystallogr D Struct Biol. 2023 Jun 1;79(Pt 6):545-555. doi: 10.1107/S205979832300325X. Epub 2023 May 25.
Acta Crystallogr D Struct Biol. 2023.
PMID: 37227091
Free PMC article.
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The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1.
Cheff DM, Huang C, Scholzen KC, Gencheva R, Ronzetti MH, Cheng Q, Hall MD, Arnér ESJ.
Cheff DM, et al. Among authors: scholzen kc.
Redox Biol. 2023 Jun;62:102703. doi: 10.1016/j.redox.2023.102703. Epub 2023 Apr 17.
Redox Biol. 2023.
PMID: 37087975
Free PMC article.
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Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe.
Zeisel L, Felber JG, Scholzen KC, Poczka L, Cheff D, Maier MS, Cheng Q, Shen M, Hall MD, Arnér ESJ, Thorn-Seshold J, Thorn-Seshold O.
Zeisel L, et al. Among authors: scholzen kc.
Chem. 2022 May 12;8(5):1493-1517. doi: 10.1016/j.chempr.2022.03.010. Epub 2022 Apr 14.
Chem. 2022.
PMID: 35936029
Free PMC article.
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Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically.
Felber JG, Poczka L, Scholzen KC, Zeisel L, Maier MS, Busker S, Theisen U, Brandstädter C, Becker K, Arnér ESJ, Thorn-Seshold J, Thorn-Seshold O.
Felber JG, et al. Among authors: scholzen kc.
Nat Commun. 2022 Apr 1;13(1):1754. doi: 10.1038/s41467-022-29136-4.
Nat Commun. 2022.
PMID: 35365603
Free PMC article.
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