Bobrovs R - Search Results

1

Ultrafast Fragment Screening Using Photo-Hyperpolarized (CIDNP) NMR.

Torres F, Bütikofer M, Stadler GR, Renn A, Kadavath H, Bobrovs R, Jaudzems K, Riek R. Torres F, et al. Among authors: bobrovs r. J Am Chem Soc. 2023 Jun 7;145(22):12066-12080. doi: 10.1021/jacs.3c01392. Epub 2023 May 25. J Am Chem Soc. 2023. PMID: 37227050 Free PMC article.

2

2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity.

Rasina D, Stakanovs G, Borysov OV, Pantelejevs T, Bobrovs R, Kanepe-Lapsa I, Tars K, Jaudzems K, Jirgensons A. Rasina D, et al. Among authors: bobrovs r. Bioorg Med Chem. 2018 May 15;26(9):2488-2500. doi: 10.1016/j.bmc.2018.04.012. Epub 2018 Apr 5. Bioorg Med Chem. 2018. PMID: 29636223

3

Azole-based non-peptidomimetic plasmepsin inhibitors.

Kinena L, Leitis G, Kanepe-Lapsa I, Bobrovs R, Jaudzems K, Ozola V, Suna E, Jirgensons A. Kinena L, et al. Among authors: bobrovs r. Arch Pharm (Weinheim). 2018 Sep;351(9):e1800151. doi: 10.1002/ardp.201800151. Epub 2018 Jul 31. Arch Pharm (Weinheim). 2018. PMID: 30063266

4

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.

Zogota R, Kinena L, Withers-Martinez C, Blackman MJ, Bobrovs R, Pantelejevs T, Kanepe-Lapsa I, Ozola V, Jaudzems K, Suna E, Jirgensons A. Zogota R, et al. Among authors: bobrovs r. Eur J Med Chem. 2019 Feb 1;163:344-352. doi: 10.1016/j.ejmech.2018.11.068. Epub 2018 Nov 29. Eur J Med Chem. 2019. PMID: 30529637 Free PMC article.

5

Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases.

Bobrovs R, Jaudzems K, Jirgensons A. Bobrovs R, et al. J Med Chem. 2019 Oct 24;62(20):8931-8950. doi: 10.1021/acs.jmedchem.9b00184. Epub 2019 May 16. J Med Chem. 2019. PMID: 31062983 Review.

6

Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization.

Jaudzems K, Kurbatska V, Je Kabsons A, Bobrovs R, Rudevica Z, Leonchiks A. Jaudzems K, et al. Among authors: bobrovs r. ACS Infect Dis. 2020 Feb 14;6(2):186-194. doi: 10.1021/acsinfecdis.9b00265. Epub 2019 Nov 18. ACS Infect Dis. 2020. PMID: 31724850

7

Structural and Functional Analysis of BBA03, Borrelia burgdorferi Competitive Advantage Promoting Outer Surface Lipoprotein.

Fridmanis J, Bobrovs R, Brangulis K, Tārs K, Jaudzems K. Fridmanis J, et al. Among authors: bobrovs r. Pathogens. 2020 Oct 9;9(10):826. doi: 10.3390/pathogens9100826. Pathogens. 2020. PMID: 33050189 Free PMC article.

8

Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate.

Bobiļeva O, Bobrovs R, Kaņepe I, Patetko L, Kalniņš G, Šišovs M, Bula AL, Gri Nberga S, Borodušķis MR, Ramata-Stunda A, Rostoks N, Jirgensons A, Ta Rs K, Jaudzems K. Bobiļeva O, et al. Among authors: bobrovs r. ACS Med Chem Lett. 2021 Jun 9;12(7):1102-1107. doi: 10.1021/acsmedchemlett.1c00140. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34257831 Free PMC article.

9

Aggregation Condition-Structure Relationship of Mouse Prion Protein Fibrils.

Fridmanis J, Toleikis Z, Sneideris T, Ziaunys M, Bobrovs R, Smirnovas V, Jaudzems K. Fridmanis J, et al. Among authors: bobrovs r. Int J Mol Sci. 2021 Sep 6;22(17):9635. doi: 10.3390/ijms22179635. Int J Mol Sci. 2021. PMID: 34502545 Free PMC article.

10

Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening.

Bobrovs R, Kanepe I, Narvaiss N, Patetko L, Kalnins G, Sisovs M, Bula AL, Grinberga S, Boroduskis M, Ramata-Stunda A, Rostoks N, Jirgensons A, Tars K, Jaudzems K. Bobrovs R, et al. Pharmaceuticals (Basel). 2021 Nov 30;14(12):1243. doi: 10.3390/ph14121243. Pharmaceuticals (Basel). 2021. PMID: 34959647 Free PMC article.

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