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Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog.
Ader M, Stefanovski D, Kim SP, Richey JM, Ionut V, Catalano KJ, Hucking K, Ellmerer M, Van Citters G, Hsu IR, Chiu JD, Woolcott OO, Harrison LN, Zheng D, Lottati M, Kolka CM, Mooradian V, Dittmann J, Yae S, Liu H, Castro AV, Kabir M, Bergman RN. Ader M, et al. Among authors: kabir m. Obesity (Silver Spring). 2014 May;22(5):1238-45. doi: 10.1002/oby.20625. Epub 2013 Dec 3. Obesity (Silver Spring). 2014. PMID: 24123967 Free PMC article.
Increase in visceral fat per se does not induce insulin resistance in the canine model.
Castro AV, Woolcott OO, Iyer MS, Kabir M, Ionut V, Stefanovski D, Kolka CM, Szczepaniak LS, Szczepaniak EW, Asare-Bediako I, Paszkiewicz RL, Broussard JL, Kim SP, Kirkman EL, Rios HC, Mkrtchyan H, Wu Q, Ader M, Bergman RN. Castro AV, et al. Among authors: kabir m. Obesity (Silver Spring). 2015 Jan;23(1):105-11. doi: 10.1002/oby.20906. Epub 2014 Oct 16. Obesity (Silver Spring). 2015. PMID: 25322680 Free PMC article.
Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs.
Richey JM, Woolcott OO, Stefanovski D, Harrison LN, Zheng D, Lottati M, Hsu IR, Kim SP, Kabir M, Catalano KJ, Chiu JD, Ionut V, Kolka C, Mooradian V, Bergman RN. Richey JM, et al. Among authors: kabir m. Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1311-8. doi: 10.1152/ajpendo.90972.2008. Epub 2009 Apr 14. Am J Physiol Endocrinol Metab. 2009. PMID: 19366874 Free PMC article.
High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets.
Woolcott OO, Richey JM, Kabir M, Chow RH, Iyer MS, Kirkman EL, Stefanovski D, Lottati M, Kim SP, Harrison LN, Ionut V, Zheng D, Hsu IR, Catalano KJ, Chiu JD, Bradshaw H, Wu Q, Kolka CM, Bergman RN. Woolcott OO, et al. Among authors: kabir m. PLoS One. 2015 Apr 9;10(4):e0123558. doi: 10.1371/journal.pone.0123558. eCollection 2015. PLoS One. 2015. PMID: 25855974 Free PMC article.
CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors.
Kabir M, Iyer MS, Richey JM, Woolcott OO, Asare Bediako I, Wu Q, Kim SP, Stefanovski D, Kolka CM, Hsu IR, Catalano KJ, Chiu JD, Ionut V, Bergman RN. Kabir M, et al. Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E747-58. doi: 10.1152/ajpendo.00196.2015. Epub 2015 Aug 25. Am J Physiol Endocrinol Metab. 2015. PMID: 26306598 Free PMC article.
Exenatide Treatment Alone Improves β-Cell Function in a Canine Model of Pre-Diabetes.
Ionut V, Woolcott OO, Mkrtchyan HJ, Stefanovski D, Kabir M, Iyer MS, Liu H, Castro AV, Wu Q, Broussard JL, Kolka CM, Asare-Bediako I, Bergman RN. Ionut V, et al. Among authors: kabir m. PLoS One. 2016 Jul 11;11(7):e0158703. doi: 10.1371/journal.pone.0158703. eCollection 2016. PLoS One. 2016. PMID: 27398720 Free PMC article.
1,322 results