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Suppression of superoxide/hydrogen peroxide production at mitochondrial site IQ decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet.
Watson MA, Brar H, Gibbs ET 2nd, Wong HS, Dighe PA, McKibben B, Riedmaier S, Siu A, Polakowski JS, Segreti JA, Liu X, Chung S, Pliushchev YM, Gesmundo N, Wang Z, Vortherms TA, Brand MD. Watson MA, et al. Among authors: polakowski js. Free Radic Biol Med. 2023 Aug 1;204:276-286. doi: 10.1016/j.freeradbiomed.2023.05.022. Epub 2023 May 20. Free Radic Biol Med. 2023. PMID: 37217089 Free article.
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
Koshman YE, Wilsey AS, Bird BM, Sadilek S, Weisbecker DA, Ebert PA, Polakowski JS, Gintant GA, Mittelstadt SW, Foley CM. Koshman YE, et al. Among authors: polakowski js. J Pharmacol Toxicol Methods. 2021 Sep-Oct;111:107109. doi: 10.1016/j.vascn.2021.107109. Epub 2021 Aug 18. J Pharmacol Toxicol Methods. 2021. PMID: 34416395 Free article.
Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities.
Koshman YE, Lai-Zhang J, Wilsey AS, Bird BM, Sadilek S, Weisbecker DA, Ebert PA, Polakowski JS, Mittelstadt SW, Foley CM, LeRoy BE. Koshman YE, et al. Among authors: polakowski js. J Pharmacol Toxicol Methods. 2021 Nov-Dec;112:107115. doi: 10.1016/j.vascn.2021.107115. Epub 2021 Aug 14. J Pharmacol Toxicol Methods. 2021. PMID: 34403748 Free article.
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
Koshman YE, Wilsey AS, Bird BM, Sadilek S, Weisbecker DA, Ebert PA, Polakowski JS, Gintant GA, Mittelstadt SW, Foley CM. Koshman YE, et al. Among authors: polakowski js. J Pharmacol Toxicol Methods. 2021 May-Jun;109:107066. doi: 10.1016/j.vascn.2021.107066. Epub 2021 Apr 7. J Pharmacol Toxicol Methods. 2021. PMID: 33838254
Automated Blood Sampling in a Canine Telemetry Cardiovascular Model.
Wilsey AS, Koshman YE, Weisbecker DA, Bird BM, Mirakhur KK, Sadilek S, Ebert PA, Polakowski JS, Foley CM, Medina CL, Mittelstadt SW. Wilsey AS, et al. Among authors: polakowski js. Comp Med. 2021 Apr 1;71(2):133-140. doi: 10.30802/AALAS-CM-20-000083. Epub 2021 Apr 4. Comp Med. 2021. PMID: 33814031 Free PMC article.
Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.
Koshman YE, Wilsey AS, Bird BM, Endemann AL, Sadilek S, Treadway J, Martin RL, Polakowski JS, Gintant GA, Mittelstadt SW. Koshman YE, et al. Among authors: polakowski js. J Pharmacol Toxicol Methods. 2020 May-Jun;103:106871. doi: 10.1016/j.vascn.2020.106871. Epub 2020 Apr 30. J Pharmacol Toxicol Methods. 2020. PMID: 32360993 Free article.
Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
Voight EA, Gomtsyan AR, Daanen JF, Perner RJ, Schmidt RG, Bayburt EK, DiDomenico S, McDonald HA, Puttfarcken PS, Chen J, Neelands TR, Bianchi BR, Han P, Reilly RM, Franklin PH, Segreti JA, Nelson RA, Su Z, King AJ, Polakowski JS, Baker SJ, Gauvin DM, Lewis LR, Mikusa JP, Joshi SK, Faltynek CR, Kym PR, Kort ME. Voight EA, et al. Among authors: polakowski js. J Med Chem. 2014 Sep 11;57(17):7412-24. doi: 10.1021/jm500916t. Epub 2014 Aug 21. J Med Chem. 2014. PMID: 25100568
40 results