Gesmundo N - Search Results

1

At the Speed of Light: The Systematic Implementation of Photoredox Cross-Coupling Reactions for Medicinal Chemistry Research.

Gesmundo NJ, Rago AJ, Young JM, Keess S, Wang Y. Gesmundo NJ, et al. J Org Chem. 2024 Mar 5. doi: 10.1021/acs.joc.3c02351. Online ahead of print. J Org Chem. 2024. PMID: 38442262 Review.

2

Suppression of superoxide/hydrogen peroxide production at mitochondrial site I_Q decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet.

Watson MA, Brar H, Gibbs ET 2nd, Wong HS, Dighe PA, McKibben B, Riedmaier S, Siu A, Polakowski JS, Segreti JA, Liu X, Chung S, Pliushchev YM, Gesmundo N, Wang Z, Vortherms TA, Brand MD. Watson MA, et al. Among authors: gesmundo n. Free Radic Biol Med. 2023 Aug 1;204:276-286. doi: 10.1016/j.freeradbiomed.2023.05.022. Epub 2023 May 20. Free Radic Biol Med. 2023. PMID: 37217089 Free article.

3

ChemBeads-Enabled Photoredox High-Throughput Experimentation Platform to Improve C(sp²)-C(sp³) Decarboxylative Couplings.

Gesmundo NJ, Tu NP, Sarris KA, Wang Y. Gesmundo NJ, et al. ACS Med Chem Lett. 2023 Mar 16;14(4):521-529. doi: 10.1021/acsmedchemlett.2c00538. eCollection 2023 Apr 13. ACS Med Chem Lett. 2023. PMID: 37077401 Free PMC article.

4

Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp²)-C(sp³) Cross-Coupling Methods by Library Synthesis.

Dombrowski AW, Gesmundo NJ, Aguirre AL, Sarris KA, Young JM, Bogdan AR, Martin MC, Gedeon S, Wang Y. Dombrowski AW, et al. Among authors: gesmundo nj. ACS Med Chem Lett. 2020 Mar 23;11(4):597-604. doi: 10.1021/acsmedchemlett.0c00093. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292569 Free PMC article.

5

Nanoscale synthesis and affinity ranking.

Gesmundo NJ, Sauvagnat B, Curran PJ, Richards MP, Andrews CL, Dandliker PJ, Cernak T. Gesmundo NJ, et al. Nature. 2018 May;557(7704):228-232. doi: 10.1038/s41586-018-0056-8. Epub 2018 Apr 23. Nature. 2018. PMID: 29686415

6

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

Cernak T, Gesmundo NJ, Dykstra K, Yu Y, Wu Z, Shi ZC, Vachal P, Sperbeck D, He S, Murphy BA, Sonatore L, Williams S, Madeira M, Verras A, Reiter M, Lee CH, Cuff J, Sherer EC, Kuethe J, Goble S, Perrotto N, Pinto S, Shen DM, Nargund R, Balkovec J, DeVita RJ, Dreher SD. Cernak T, et al. Among authors: gesmundo nj. J Med Chem. 2017 May 11;60(9):3594-3605. doi: 10.1021/acs.jmedchem.6b01543. Epub 2017 Mar 2. J Med Chem. 2017. PMID: 28252959

7

Amide and amine nucleophiles in polar radical crossover cycloadditions: synthesis of γ-lactams and pyrrolidines.

Gesmundo NJ, Grandjean JM, Nicewicz DA. Gesmundo NJ, et al. Org Lett. 2015 Mar 6;17(5):1316-9. doi: 10.1021/acs.orglett.5b00316. Epub 2015 Feb 19. Org Lett. 2015. PMID: 25695366

8

Cyclization-endoperoxidation cascade reactions of dienes mediated by a pyrylium photoredox catalyst.

Gesmundo NJ, Nicewicz DA. Gesmundo NJ, et al. Beilstein J Org Chem. 2014 Jun 3;10:1272-81. doi: 10.3762/bjoc.10.128. eCollection 2014. Beilstein J Org Chem. 2014. PMID: 24991279 Free PMC article.

9

Hydroxystearic acid effects on CDC2/histone H1 kinase activity in C108 carcinoma cells.

Casali E, Gesmundo N, Farruggia G, Spisni A, Masotti L. Casali E, et al. Among authors: gesmundo n. Biochem Biophys Res Commun. 1994 Sep 30;203(3):1385-91. doi: 10.1006/bbrc.1994.2338. Biochem Biophys Res Commun. 1994. PMID: 7945285

10

In vitro effects of hydroxystearic acid on the proliferation of HT29 and I407 cells.

Gesmundo N, Casali E, Farruggia G, Spisni A, Masotti L. Gesmundo N, et al. Biochem Mol Biol Int. 1994 Jul;33(4):705-12. Biochem Mol Biol Int. 1994. PMID: 7981658

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