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Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood.
Environ Toxicol Pharmacol. 2023 Jun;100:104152. doi: 10.1016/j.etap.2023.104152. Epub 2023 May 18.
Environ Toxicol Pharmacol. 2023.
PMID: 37209889
Free PMC article.
Morphological and transcriptomic alterations in neonatal lamb testes following developmental exposure to low-level environmental chemical mixture.
Elcombe CS, Monteiro A, Ghasemzadeh-Hasankolaei M, Evans NP, Bellingham M.
Elcombe CS, et al.
Environ Toxicol Pharmacol. 2021 Aug;86:103670. doi: 10.1016/j.etap.2021.103670. Epub 2021 May 5.
Environ Toxicol Pharmacol. 2021.
PMID: 33964400
Free PMC article.
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Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs.
Elcombe CS, Monteiro A, Elcombe MR, Ghasemzadeh-Hasankolaei M, Sinclair KD, Lea R, Padmanabhan V, Evans NP, Bellingham M.
Elcombe CS, et al.
Environ Toxicol Pharmacol. 2022 Aug;94:103913. doi: 10.1016/j.etap.2022.103913. Epub 2022 Jun 20.
Environ Toxicol Pharmacol. 2022.
PMID: 35738462
Free PMC article.
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Critical review and analysis of literature on low dose exposure to chemical mixtures in mammalian in vivo systems.
Elcombe CS, Evans NP, Bellingham M.
Elcombe CS, et al.
Crit Rev Toxicol. 2022 Mar;52(3):221-238. doi: 10.1080/10408444.2022.2091423. Epub 2022 Jul 27.
Crit Rev Toxicol. 2022.
PMID: 35894754
Free PMC article.
Review.
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Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep.
Evans NP, Bellingham M, Elcombe CS, Ghasemzadeh-Hasankolaei M, Lea RG, Sinclair KD, Padmanabhan V.
Evans NP, et al. Among authors: elcombe cs.
Environ Toxicol Pharmacol. 2023 Sep;102:104257. doi: 10.1016/j.etap.2023.104257. Epub 2023 Sep 1.
Environ Toxicol Pharmacol. 2023.
PMID: 37659607
Free PMC article.
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Preconceptional and in utero exposure of sheep to a real-life environmental chemical mixture disrupts key markers of energy metabolism in male offspring.
Ghasemzadeh-Hasankolaei M, Elcombe CS, Powls S, Lea RG, Sinclair KD, Padmanabhan V, Evans NP, Bellingham M.
Ghasemzadeh-Hasankolaei M, et al. Among authors: elcombe cs.
J Neuroendocrinol. 2024 Jan;36(1):e13358. doi: 10.1111/jne.13358. Epub 2023 Dec 12.
J Neuroendocrinol. 2024.
PMID: 38087451
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