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An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability.
Jain K, Marunde MR, Burg JM, Gloor SL, Joseph FM, Poncha KF, Gillespie ZB, Rodriguez KL, Popova IK, Hall NW, Vaidya A, Howard SA, Taylor HF, Mukhsinova L, Onuoha UC, Patteson EF, Cooke SW, Taylor BC, Weinzapfel EN, Cheek MA, Meiners MJ, Fox GC, Namitz KEW, Cowles MW, Krajewski K, Sun ZW, Cosgrove MS, Young NL, Keogh MC, Strahl BD. Jain K, et al. Among authors: cosgrove ms. Elife. 2023 May 19;12:e82596. doi: 10.7554/eLife.82596. Elife. 2023. PMID: 37204295 Free PMC article.
Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS. Patel A, et al. Among authors: cosgrove ms. J Biol Chem. 2014 Jan 10;289(2):868-84. doi: 10.1074/jbc.M113.501064. Epub 2013 Nov 14. J Biol Chem. 2014. PMID: 24235145 Free PMC article.
Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Rahman S, Hoffmann NA, Worden EJ, Smith ML, Namitz KEW, Knutson BA, Cosgrove MS, Wolberger C. Rahman S, et al. Among authors: cosgrove ms. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2205691119. doi: 10.1073/pnas.2205691119. Epub 2022 Sep 12. Proc Natl Acad Sci U S A. 2022. PMID: 36095189 Free PMC article.
54 results