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A two-pronged attack.
Feng JJ, Zhang C. Feng JJ, et al. Among authors: zhang c. Nat Chem Biol. 2020 Nov;16(11):1154-1155. doi: 10.1038/s41589-020-0647-1. Nat Chem Biol. 2020. PMID: 33067596 No abstract available.
Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases.
Assadieskandar A, Yu C, Maisonneuve P, Kurinov I, Sicheri F, Zhang C. Assadieskandar A, et al. Among authors: zhang c. ACS Med Chem Lett. 2019 Jun 4;10(7):1074-1080. doi: 10.1021/acsmedchemlett.9b00194. eCollection 2019 Jul 11. ACS Med Chem Lett. 2019. PMID: 31312411 Free PMC article.
Covalent Modulators of the Vacuolar ATPase.
Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. Chen YC, et al. Among authors: zhang c. J Am Chem Soc. 2017 Jan 18;139(2):639-642. doi: 10.1021/jacs.6b12511. Epub 2016 Dec 30. J Am Chem Soc. 2017. PMID: 28010062 Free PMC article.
Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease.
Ngo C, Fried W, Aliyari S, Feng J, Qin C, Zhang S, Yang H, Shanaa J, Feng P, Cheng G, Chen XS, Zhang C. Ngo C, et al. Among authors: zhang s, zhang c. J Med Chem. 2023 Sep 14;66(17):12237-12248. doi: 10.1021/acs.jmedchem.3c00810. Epub 2023 Aug 18. J Med Chem. 2023. PMID: 37595260 Free PMC article.
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