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Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Wellington CL, et al. J Neurosci. 2002 Sep 15;22(18):7862-72. doi: 10.1523/JNEUROSCI.22-18-07862.2002. J Neurosci. 2002. PMID: 12223539 Free PMC article.
Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.
Pinto JT, Van Raamsdonk JM, Leavitt BR, Hayden MR, Jeitner TM, Thaler HT, Krasnikov BF, Cooper AJ. Pinto JT, et al. Among authors: van raamsdonk jm. J Neurochem. 2005 Aug;94(4):1087-101. doi: 10.1111/j.1471-4159.2005.03255.x. Epub 2005 Jun 30. J Neurochem. 2005. PMID: 15992377 Free article.
Wild-type huntingtin protects neurons from excitotoxicity.
Leavitt BR, van Raamsdonk JM, Shehadeh J, Fernandes H, Murphy Z, Graham RK, Wellington CL, Raymond LA, Hayden MR. Leavitt BR, et al. Among authors: van raamsdonk jm. J Neurochem. 2006 Feb;96(4):1121-9. doi: 10.1111/j.1471-4159.2005.03605.x. Epub 2006 Jan 17. J Neurochem. 2006. PMID: 16417581 Free article.
67 results