Lu G - Search Results

1

Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice.

Van Raamsdonk JM, Al-Shekaili HH, Wagner L, Bredy TW, Chan L, Pearson J, Schwab C, Murphy Z, Devon RS, Lu G, Kobor MS, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: lu g. Aging Dis. 2023 Dec 1;14(6):2249-2266. doi: 10.14336/AD.2023.0423. Aging Dis. 2023. PMID: 37199581 Free PMC article.

2

Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models.

Chan LL, Hill A, Lu G, Van Raamsdonk J, Gascoyne R, Hayden MR, Leavitt BR. Chan LL, et al. Among authors: lu g. J Huntingtons Dis. 2022;11(4):383-389. doi: 10.3233/JHD-220554. J Huntingtons Dis. 2022. PMID: 36442204

3

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.

Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y, Pearson J, Vaid K, Bissada N, Wetzel R, Leavitt BR, Hayden MR. Slow EJ, et al. Among authors: lu g. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11402-7. doi: 10.1073/pnas.0503634102. Epub 2005 Aug 2. Proc Natl Acad Sci U S A. 2005. PMID: 16076956 Free PMC article.

4

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Rogers DA, Lu G, Barakauskas VE, Barr AM, Honer WG, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: lu g. Exp Neurol. 2005 Dec;196(2):266-72. doi: 10.1016/j.expneurol.2005.07.021. Epub 2005 Aug 29. Exp Neurol. 2005. PMID: 16129433

5

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.

Graham RK, Slow EJ, Deng Y, Bissada N, Lu G, Pearson J, Shehadeh J, Leavitt BR, Raymond LA, Hayden MR. Graham RK, et al. Among authors: lu g. Neurobiol Dis. 2006 Feb;21(2):444-55. doi: 10.1016/j.nbd.2005.08.007. Epub 2005 Oct 17. Neurobiol Dis. 2006. PMID: 16230019

6

Body weight is modulated by levels of full-length huntingtin.

Van Raamsdonk JM, Gibson WT, Pearson J, Murphy Z, Lu G, Leavitt BR, Hayden MR. Van Raamsdonk JM, et al. Among authors: lu g. Hum Mol Genet. 2006 May 1;15(9):1513-23. doi: 10.1093/hmg/ddl072. Epub 2006 Mar 28. Hum Mol Genet. 2006. PMID: 16571604

7

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Graham RK, et al. Among authors: lu g. Cell. 2006 Jun 16;125(6):1179-91. doi: 10.1016/j.cell.2006.04.026. Cell. 2006. PMID: 16777606 Free article.

8

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

Metzler M, Gan L, Mazarei G, Graham RK, Liu L, Bissada N, Lu G, Leavitt BR, Hayden MR. Metzler M, et al. Among authors: lu g. J Neurosci. 2010 Oct 27;30(43):14318-29. doi: 10.1523/JNEUROSCI.1589-10.2010. J Neurosci. 2010. PMID: 20980587 Free PMC article.

9

Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.

Petkau TL, Zhu S, Lu G, Fernando S, Cynader M, Leavitt BR. Petkau TL, et al. Among authors: lu g. Neurobiol Aging. 2013 Nov;34(11):2548-50. doi: 10.1016/j.neurobiolaging.2013.04.019. Epub 2013 May 21. Neurobiol Aging. 2013. PMID: 23702345

10

Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons.

Park KH, Lu G, Fan J, Raymond LA, Leavitt BR. Park KH, et al. Among authors: lu g. J Huntingtons Dis. 2012;1(1):89-96. doi: 10.3233/JHD-2012-129000. J Huntingtons Dis. 2012. PMID: 24353748 Free PMC article.

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