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Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology.
Suelves N, Saleki S, Ibrahim T, Palomares D, Moonen S, Koper MJ, Vrancx C, Vadukul DM, Papadopoulos N, Viceconte N, Claude E, Vandenberghe R, von Arnim CAF, Constantinescu SN, Thal DR, Decottignies A, Kienlen-Campard P. Suelves N, et al. Among authors: kienlen campard p. Acta Neuropathol Commun. 2023 May 17;11(1):82. doi: 10.1186/s40478-023-01578-x. Acta Neuropathol Commun. 2023. PMID: 37198698 Free PMC article.
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.
Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, Fei JZ, Aimoto S, Courtoy PJ, Smith SO, Constantinescu SN, Octave JN. Kienlen-Campard P, et al. J Biol Chem. 2008 Mar 21;283(12):7733-44. doi: 10.1074/jbc.M707142200. Epub 2008 Jan 16. J Biol Chem. 2008. PMID: 18201969 Free PMC article.
What is the role of amyloid precursor protein dimerization?
Khalifa NB, Van Hees J, Tasiaux B, Huysseune S, Smith SO, Constantinescu SN, Octave JN, Kienlen-Campard P. Khalifa NB, et al. Cell Adh Migr. 2010 Apr-Jun;4(2):268-72. doi: 10.4161/cam.4.2.11476. Epub 2010 Apr 11. Cell Adh Migr. 2010. PMID: 20400860 Free PMC article.
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.
Stancu IC, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D, Dewachter I. Stancu IC, et al. Acta Neuropathol. 2015 Jun;129(6):875-94. doi: 10.1007/s00401-015-1413-4. Epub 2015 Apr 11. Acta Neuropathol. 2015. PMID: 25862635 Free PMC article.
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.
Vasconcelos B, Stancu IC, Buist A, Bird M, Wang P, Vanoosthuyse A, Van Kolen K, Verheyen A, Kienlen-Campard P, Octave JN, Baatsen P, Moechars D, Dewachter I. Vasconcelos B, et al. Acta Neuropathol. 2016 Apr;131(4):549-69. doi: 10.1007/s00401-015-1525-x. Epub 2016 Jan 6. Acta Neuropathol. 2016. PMID: 26739002 Free PMC article.
60 results