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Polygenic scoring accuracy varies across the genetic ancestry continuum.
Ding Y, Hou K, Xu Z, Pimplaskar A, Petter E, Boulier K, Privé F, Vilhjálmsson BJ, Olde Loohuis LM, Pasaniuc B. Ding Y, et al. Among authors: vilhjalmsson bj. Nature. 2023 Jun;618(7966):774-781. doi: 10.1038/s41586-023-06079-4. Epub 2023 May 17. Nature. 2023. PMID: 37198491 Free PMC article.
Quantifying missing heritability at known GWAS loci.
Gusev A, Bhatia G, Zaitlen N, Vilhjalmsson BJ, Diogo D, Stahl EA, Gregersen PK, Worthington J, Klareskog L, Raychaudhuri S, Plenge RM, Pasaniuc B, Price AL. Gusev A, et al. Among authors: vilhjalmsson bj. PLoS Genet. 2013;9(12):e1003993. doi: 10.1371/journal.pgen.1003993. Epub 2013 Dec 26. PLoS Genet. 2013. PMID: 24385918 Free PMC article.
Leveraging population admixture to characterize the heritability of complex traits.
Zaitlen N, Pasaniuc B, Sankararaman S, Bhatia G, Zhang J, Gusev A, Young T, Tandon A, Pollack S, Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S, Franceschini N, Goodman PG, He J, Hennis AJ, Hsing A, Ingles SA, Isaacs W, Kittles RA, Klein EA, Lange LA, Nemesure B, Patterson N, Reich D, Rybicki BA, Stanford JL, Stevens VL, Strom SS, Whitsel EA, Witte JS, Xu J, Haiman C, Wilson JG, Kooperberg C, Stram D, Reiner AP, Tang H, Price AL. Zaitlen N, et al. Among authors: vilhjalmsson bj. Nat Genet. 2014 Dec;46(12):1356-62. doi: 10.1038/ng.3139. Epub 2014 Nov 10. Nat Genet. 2014. PMID: 25383972 Free PMC article.
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.
Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study; Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL. Vilhjálmsson BJ, et al. Am J Hum Genet. 2015 Oct 1;97(4):576-92. doi: 10.1016/j.ajhg.2015.09.001. Am J Hum Genet. 2015. PMID: 26430803 Free PMC article.
Making the Most of Clumping and Thresholding for Polygenic Scores.
Privé F, Vilhjálmsson BJ, Aschard H, Blum MGB. Privé F, et al. Among authors: vilhjalmsson bj. Am J Hum Genet. 2019 Dec 5;105(6):1213-1221. doi: 10.1016/j.ajhg.2019.11.001. Epub 2019 Nov 21. Am J Hum Genet. 2019. PMID: 31761295 Free PMC article.
Headaches and polygenic scores.
Vilhjálmsson BJ, Privé F. Vilhjálmsson BJ, et al. Neurol Genet. 2019 Oct 24;5(6):e368. doi: 10.1212/NXG.0000000000000368. eCollection 2019 Dec. Neurol Genet. 2019. PMID: 31872052 Free PMC article. No abstract available.
Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder.
Østergaard SD, Trabjerg BB, Als TD, Climent CA, Privé F, Vilhjálmsson BJ, Bækvad-Hansen M, Bybjerg-Grauholm J, Hougaard DM, Nordentoft M, Werge T, Demontis D, Mortensen PB, Børglum AD, Mors O, Agerbo E. Østergaard SD, et al. Among authors: vilhjalmsson bj. Transl Psychiatry. 2020 Oct 2;10(1):335. doi: 10.1038/s41398-020-01019-6. Transl Psychiatry. 2020. PMID: 33009369 Free PMC article.
LDpred2: better, faster, stronger.
Privé F, Arbel J, Vilhjálmsson BJ. Privé F, et al. Among authors: vilhjalmsson bj. Bioinformatics. 2021 Apr 1;36(22-23):5424-5431. doi: 10.1093/bioinformatics/btaa1029. Bioinformatics. 2021. PMID: 33326037 Free PMC article.
87 results