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A randomized single and multiple ascending dose study in healthy volunteers of LTI-291, a centrally penetrant glucocerebrosidase activator.
den Heijer JM, Kruithof AC, van Amerongen G, de Kam ML, Thijssen E, Grievink HW, Moerland M, Walker M, Been K, Skerlj R, Justman C, Dudgeon L, Lansbury P, Cullen VC, Hilt DC, Groeneveld GJ. den Heijer JM, et al. Among authors: kruithof ac. Br J Clin Pharmacol. 2021 Sep;87(9):3561-3573. doi: 10.1111/bcp.14772. Epub 2021 Mar 2. Br J Clin Pharmacol. 2021. PMID: 33576113 Free PMC article.
Characterization of the Pharmacokinetic and Pharmacodynamic Profile of Apraglutide, a Glucagon-Like Peptide-2 Analog, in Healthy Volunteers.
Bolognani F, Kruithof AC, Schulthess P, Machacek M, de Kam ML, Bergmann KR, van Gent M, Moerland M, Crenn P, Greig G, Gal P. Bolognani F, et al. Among authors: kruithof ac. J Pharmacol Exp Ther. 2023 Aug;386(2):129-137. doi: 10.1124/jpet.123.001582. Epub 2023 Jun 14. J Pharmacol Exp Ther. 2023. PMID: 37316329 Clinical Trial.
Interactions of sugammadex with various anticoagulants
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Kruithof AC, Kluft C, de Kam PJ, Laterveer GH, Moerland M, Burggraaf J. Kruithof AC, et al. Int J Clin Pharmacol Ther. 2020 Jul;58(7):395-403. doi: 10.5414/CP203733. Int J Clin Pharmacol Ther. 2020. PMID: 32383642
The mode of action of sugammadex on coagulation.
Kruithof AC, Kluft C, de Kam PJ, Laterveer RH, Moerland M, Burggraaf J. Kruithof AC, et al. Int J Clin Pharmacol Ther. 2021 Feb;59(2):89-98. doi: 10.5414/CP203858. Int J Clin Pharmacol Ther. 2021. PMID: 33155541
Lack of a clinically relevant effect of sugammadex on anti-Xa activity or activated partial thromboplastin time following pretreatment with either unfractionated or low-molecular-weight heparin in healthy subjects.
De Kam PJ, Kruithof AC, van Lierop MJ, Moerland M, Dennie J, Troyer MD, Langdon RB, Gutstein DE, Burggraaf J, El Galta R. De Kam PJ, et al. Among authors: kruithof ac. Int J Clin Pharmacol Ther. 2014 Aug;52(8):631-41. doi: 10.5414/CP202091. Int J Clin Pharmacol Ther. 2014. PMID: 24800921 Clinical Trial.
A PK-PD model-based assessment of sugammadex effects on coagulation parameters.
Bosch R, van Lierop MJ, de Kam PJ, Kruithof AC, Burggraaf J, de Greef R, Visser SA, Johnson-Levonas AO, Kleijn HJ. Bosch R, et al. Among authors: kruithof ac. Eur J Pharm Sci. 2016 Mar 10;84:9-17. doi: 10.1016/j.ejps.2015.12.028. Epub 2015 Dec 30. Eur J Pharm Sci. 2016. PMID: 26747019 Clinical Trial.
16 results