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The use of biomarkers in human pharmacology (Phase I) studies.
Cohen AF, Burggraaf J, van Gerven JM, Moerland M, Groeneveld GJ. Cohen AF, et al. Among authors: groeneveld gj. Annu Rev Pharmacol Toxicol. 2015;55:55-74. doi: 10.1146/annurev-pharmtox-011613-135918. Epub 2014 Oct 6. Annu Rev Pharmacol Toxicol. 2015. PMID: 25292425 Review.
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Grievink HW, Heuberger JAAC, Huang F, Chaudhary R, Birkhoff WAJ, Tonn GR, Mosesova S, Erickson R, Moerland M, Haddick PCG, Scearce-Levie K, Ho C, Groeneveld GJ. Grievink HW, et al. Among authors: groeneveld gj. Clin Pharmacol Ther. 2020 Feb;107(2):406-414. doi: 10.1002/cpt.1615. Epub 2019 Sep 25. Clin Pharmacol Ther. 2020. PMID: 31437302 Clinical Trial.
Challenging the challenge: A randomized controlled trial evaluating the inflammatory response and pain perception of healthy volunteers after single-dose LPS administration, as a potential model for inflammatory pain in early-phase drug development.
Hijma HJ, Moss LM, Gal P, Ziagkos D, de Kam ML, Moerland M, Groeneveld GJ. Hijma HJ, et al. Among authors: groeneveld gj. Brain Behav Immun. 2020 Aug;88:515-528. doi: 10.1016/j.bbi.2020.04.033. Epub 2020 Apr 16. Brain Behav Immun. 2020. PMID: 32305572 Free article. Clinical Trial.
A Large-Scale Full GBA1 Gene Screening in Parkinson's Disease in the Netherlands.
den Heijer JM, Cullen VC, Quadri M, Schmitz A, Hilt DC, Lansbury P, Berendse HW, van de Berg WDJ, de Bie RMA, Boertien JM, Boon AJW, Contarino MF, van Hilten JJ, Hoff JI, van Mierlo T, Munts AG, van der Plas AA, Ponsen MM, Baas F, Majoor-Krakauer D, Bonifati V, van Laar T, Groeneveld GJ. den Heijer JM, et al. Among authors: groeneveld gj. Mov Disord. 2020 Sep;35(9):1667-1674. doi: 10.1002/mds.28112. Epub 2020 Jul 2. Mov Disord. 2020. PMID: 32618053 Free PMC article.
Safety, pharmacokinetics and pharmacodynamics of SBT-020 in patients with early stage Huntington's disease, a 2-part study.
van Diemen MPJ, Hart EP, Abbruscato A, Mead L, van Beelen I, Bergheanu SC, Hameeteman PW, Coppen E, Winder JY, Moerland M, Kan H, van der Grond J, Webb A, Roos RAC, Groeneveld GJ. van Diemen MPJ, et al. Among authors: groeneveld gj. Br J Clin Pharmacol. 2021 May;87(5):2290-2302. doi: 10.1111/bcp.14656. Epub 2020 Dec 29. Br J Clin Pharmacol. 2021. PMID: 33197078 Free PMC article. Clinical Trial.
Experience in Genetic Counseling for GBA1 Variants in Parkinson's Disease.
den Heijer JM, van Hilten JJ, Kievit AJA, Bonifati V, Groeneveld GJ. den Heijer JM, et al. Among authors: groeneveld gj. Mov Disord Clin Pract. 2020 Oct 27;8(1):33-36. doi: 10.1002/mdc3.13098. eCollection 2021 Jan. Mov Disord Clin Pract. 2020. PMID: 33426156 Free PMC article. No abstract available.
142 results